A9KS12

PR
Gene name
secA
Protein name
Protein translocase subunit SecA
Names
Species
Lachnoclostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg) (Clostridium phytofermentans)
KEGG Pathway
cpy:Cphy_0256
EC number
7.4.2.8: Linked to the hydrolysis of a nucleoside triphosphate
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

554-647 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A9KS12

Entry ID Method Resolution Chain Position Source
AF-A9KS12-F1 Predicted AlphaFoldDB

No variants for A9KS12

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A9KS12

No associated diseases with A9KS12

9 regional properties for A9KS12

Type Name Position InterPro Accession
domain Helicase, C-terminal 421 - 605 IPR001650
conserved_site SEC-C motif 837 - 853 IPR004027
domain SecA DEAD-like, N-terminal 4 - 401 IPR011115
domain SecA Wing/Scaffold 588 - 799 IPR011116
domain SecA, preprotein cross-linking domain 226 - 357 IPR011130
domain Helicase superfamily 1/2, ATP-binding domain 87 - 225 IPR014001
domain SecA motor DEAD 1 - 589 IPR014018
conserved_site SecA conserved site 499 - 514 IPR020937
domain SecA, C-terminal helicase domain 419 - 559 IPR044722

Functions

Description
EC Number 7.4.2.8 Linked to the hydrolysis of a nucleoside triphosphate
Subcellular Localization
  • Cell membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Cytoplasm
  • Distribution is 50-50
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
protein-exporting ATPase activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + protein+(in) -> ADP + phosphate + protein+(out); drives the concomitant secretion of proteins.

3 GO annotations of biological process

Name Definition
intracellular protein transmembrane transport The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore.
protein import The targeting and directed movement of proteins into a cell or organelle. Not all import involves an initial targeting event.
protein targeting The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGLIKKIFGT HSEREIKLIR PTADKIEALE PDMMKLSDDE LRGKTIEFKN RLKNGETLDD
70 80 90 100 110 120
ILVEAYAVVR EAAKRTLGNR AYYVQLLGGI ILHQGRISEM RTGEGKTLTS TFPAYLNALE
130 140 150 160 170 180
GEGVHIVTVN DYLAKRDAEW MGEVHRFLGL SVGCILNDMD NDERRKAYNC DITYATNNEL
190 200 210 220 230 240
GFDYLRDNMV IYKEQLVMRD LHFAIIDEVD SVLIDEARTP LIISGQSGKS TRLYEACDIL
250 260 270 280 290 300
ARQLTKGTAK ELSKMDIIMK EDDQETGDFV VNEKEKAVNL TAEGVEKVER FFKIENLADP
310 320 330 340 350 360
ENLEIQHNII LALRAHYLMA IDKDYVVKDD EVLIVDDFTG RIMPGRRYSD GLHQAIEAKE
370 380 390 400 410 420
HVKVKRESKT LATITFQNFF NKYTKKCGMT GTALTEENEF REIYGMDVVE VPTNRPVARI
430 440 450 460 470 480
DKDDAVYRTK REKLNAVINA IVEAHKAGQP VLVGTITIEA SEEISELLKK KNIPHKVLNA
490 500 510 520 530 540
KFHELEAEII ADAGQKGAVT IATNMAGRGT DIKLGEGVTE LGGLKIIGTE RHESRRIDNQ
550 560 570 580 590 600
LRGRSGRQGD PGESCFYICL EDDLMRLFGS ERLNTIFKSL GLPEGEQIEH KMLSGAIEKA
610 620 630 640 650 660
QKKIEDNNFG IRKNLLEYDK VNNEQREIIY AERRKVLNGD SMRDVIFKMI TDNVETCVNT
670 680 690 700 710 720
SISDDQLPEE WDLAELNQML LPIIPMEPVE LKDNELRHMK RNELIHMLKE KAVKLYEEKE
730 740 750 760 770 780
AEFPEKEHLR EVERVVLLRV IDRKWMDHID DMDQLRQGIG LQAYGQRDPK TEYKFSGFEM
790 800 810 820 830 840
FDTMINAITE DTVKALMHVR IEQKVEREEV AKVTGTNRDE SVAKAPVKRA TKKVQPNDPC
850
PCGSGKKYKH CCGGVGRI