A9JR23

PR
Gene name
L
Protein name
RNA-directed RNA polymerase L
Names
Protein L, Large structural protein, Replicase, Transcriptase
Species
Tamiami mammarenavirus (isolate Rat/United States/W 10777/1964) (TAMV)
KEGG Pathway
vg:6301275
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

887-964 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

0 structures for A9JR23

Entry ID Method Resolution Chain Position Source

3 variants for A9JR23

Variant ID(s) Position Change Description Diseaes Association Provenance
402 K>R No
549 R>G No
555 L>KV No

No associated diseases with A9JR23

2 regional properties for A9JR23

Type Name Position InterPro Accession
domain RNA-directed RNA polymerase, negative-strand RNA virus 1167 - 1369 IPR007099
domain RNA endonuclease, cap-snatching 9 - 171 IPR026382

Functions

Description
EC Number
Subcellular Localization
  • Virion
  • Host cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
host cell cytoplasm The cytoplasm of a host cell.
virion component Any constituent part of a virion, a complete fully infectious extracellular virus particle.

3 GO annotations of molecular function

Name Definition
hydrolase activity Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
nucleotide binding Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
RNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.

3 GO annotations of biological process

Name Definition
cap snatching A transcription initiation process during which a nucleotide sequence between 10 and 20 nucleotides in size is cleaved from the 5' end of host mRNAs by a viral RNA-dependent polymerase. The capped leader sequence obtained is subsequently used to prime transcription on the viral genome, which ultimately leads to the synthesis of capped, translatable viral mRNAs.
negative stranded viral RNA replication A viral genome replication process where the template genome is negative stranded, single stranded RNA ((-)ssRNA).
RNA-templated viral transcription A transcription process that uses viral RNA as a template.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSECLTYFNE LKDLVRKWVP DEDTYVEQKT VLLSQVNFSS IVTEGLKLLS TLIEVDSCVK
70 80 90 100 110 120
HGCIHNRSKT VNQILYDHRI VGPTLPDVVP DGYRVSGSTL ILLETFVRVN QESFECKYRH
130 140 150 160 170 180
DFEKLMQLSK DLAKCGLTLV PVIDGRSSYY IERLPDWVIE RMRWLLLRIM SNLRDSGEKI
190 200 210 220 230 240
EEMEYERLVH SLSNMENQNL GLESLASLRE EGLDYKTRLT KTLKEGIYSN MTTSECRVGI
250 260 270 280 290 300
AKLYDHFCLL RDSGQYEDVY TTTSRSEMIT WLKTHELVQM SSSERETLIE AETCKFCQIH
310 320 330 340 350 360
MYAVLKDLVL LRKGWKGSRC RDANEILAHK SLLSDCNKIK GLKVLNTRRN TLLCLDIIVL
370 380 390 400 410 420
NSLINLIKLQ YTDLQYLINN HFKSVNDRLV SVDLIINKLD KKLTSDPNWL CKLRTKIGHK
430 440 450 460 470 480
LKIYDLDHVI SWLRPIEVSH WYEFKLERDN SGECVKPTIK YKKSGVGDCQ GEDCNKDVIT
490 500 510 520 530 540
DDSTFSDYLD ALSTLSMGLM NSMKTSSATK LVVNDERNYF GTVQCDECYF QDLDINYGTT
550 560 570 580 590 600
LIYQKTGERT RCYGLMSKEG GGPDVYKVGK SFYADPKRYF LPIMSSEVIL KMCREMLSWL
610 620 630 640 650 660
DWLSEKEMMD VRTKLYTLVI SILTVPSKRV QIYLQGFRYF IMAYVNEFHV KELVCKLKVK
670 680 690 700 710 720
PLTRAELSVF TQMDDLVALL LTGTSEEHMT KSFKFILNLS YLCHLITKET PDRLTDQIKC
730 740 750 760 770 780
FEKFLEPKLT FNSVILNLDS SPQLTEGTEE KIIGDLKKLF SKDLGVLDLK EPGVSKEVLS
790 800 810 820 830 840
LCSSCFNNGM LSLPKVLSRD PQSPSFTSTA LDISSNKSVV VPKLNEVGET ITQYDYQSLL
850 860 870 880 890 900
SSVVVEMAQS FKDKLRFKLD RRSLQYAIYK RLTNMVSKNE FRSKDDPNDS GILEDIEDLV
910 920 930 940 950 960
DEGTHKLINE IEANVSDCLS KMSSGCNKSN QSSKGLKKFE KVDLLQKLWS REYMSLILSE
970 980 990 1000 1010 1020
TSFHEVKDFD PSLLPSESYQ EMCDAVYDSV YRNEFFTEKF LKLCPLELLI KNLATKHYEE
1030 1040 1050 1060 1070 1080
GDYFECFKYL LIGAGCDNRV GRFDHRSRAR LGFKDTATLV KEESRISSRE SNSEAISKRL
1090 1100 1110 1120 1130 1140
DKSFFTNSSL RNLCFYSEES PTYRSSVSSS VGKLKFGLSY KEQVGSNREL YIGDLNTKLT
1150 1160 1170 1180 1190 1200
SRLIEDYFES LTSECRFSCL NNDSEFERAL LDMKSVVRLS GLAVSLDHSK WGPYMSPAIF
1210 1220 1230 1240 1250 1260
NALFSNLDLQ LKDGGLIDKS PIENLLNWHL HKIVEVPYNV VEAYLKGYTK RSLGLMDRSS
1270 1280 1290 1300 1310 1320
SSMTEDYFFR QFAKGVVPSH ITSVLDMGQG ILHNASDYYG LLTEQFITLC LELCFDVKMT
1330 1340 1350 1360 1370 1380
AYTSSDDEIM LSNSYSLKRE SDDDLLDMEK CKEILEFHYY LSSKLNKFIS PKTVAGSFAS
1390 1400 1410 1420 1430 1440
EFKSRFFIWS QEVPLLTKFV AAALHNVKAK SPHQLAETID TILDQCAANG VSIEIINELS
1450 1460 1470 1480 1490 1500
KRTNRLISYS GHPVDPFLCV FTTDLKDWVD GSRGYRLQRS IESIINSEEI LSTIRDSCRQ
1510 1520 1530 1540 1550 1560
LFYMIRSGRI QEEYLISALQ SSPDDCLRQM LKITGTNDSL IEEALTTRWL NLRAFGDLRL
1570 1580 1590 1600 1610 1620
VLRTKIMTGT RILDKEEVPS LIKSVQSKLS KNFVRGAKKI ITDAINKSAF QSSICSGFIG
1630 1640 1650 1660 1670 1680
LCKSMGSKCV RDGSGGFIYI KDLLKKIDRH TNCEVCCPLL SVFCEHSLRQ VAPYSRPLLW
1690 1700 1710 1720 1730 1740
DYFSLTFSNA CELGNWVFSK VELPRPPLGS MNPNFFWPVK PGSHSELEDK VNMNHVLYSI
1750 1760 1770 1780 1790 1800
KRNFPDLFDE HIAPFLSDLN SLKVSWVQRI KFLDLCVAMD MSSECLGIIS HIMRKRREEL
1810 1820 1830 1840 1850 1860
YIVKQEELSV CHIRESCSLE KGLQLNSVEI CQNFLTQLLF ESMLNPVLLS TSQFKKYFWY
1870 1880 1890 1900 1910 1920
GEVEFLPNDA DHDLGQLTQF IMDCKLLNIS RCMCLDDLDV GYVHSKIELS QVFINLSTFI
1930 1940 1950 1960 1970 1980
NLVDWENRES YQSFDEVLIH SNADHIPLEI GIILSHTRKS FKFRYERKTN YYVKCGITIQ
1990 2000 2010 2020 2030 2040
KSEISSFSTT LSDGFELHVE EIDCYVSGSE GDHISLDGVG LVPLHPLFSG KEALDLNKLL
2050 2060 2070 2080 2090 2100
SDQDIEFKQI SLVFSKVKLD FKDHVKDLKN KFSYKLQGPE QGLEPLHLDK GQIMERNTVV
2110 2120 2130 2140 2150 2160
SRLEVPVTSR SLFLALEALD PGNRPRFLSS LHEYMRKRPG KKDPCFVRMT QQDLCLLVEL
2170 2180 2190 2200 2210 2220
YEAAFMQVLS AVSDWIEFGC FALCFSKTLN CIMIADDGGD YRLKGRPCKT LSAQKTLTDI
E