A9BIJ7

PR
Gene name
valS
Protein name
Valine--tRNA ligase
Names
Valyl-tRNA synthetase, ValRS
Species
Petrotoga mobilis (strain DSM 10674 / SJ95)
KEGG Pathway
pmo:Pmob_1457
EC number
6.1.1.9: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

813-874 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A9BIJ7

Entry ID Method Resolution Chain Position Source
AF-A9BIJ7-F1 Predicted AlphaFoldDB

No variants for A9BIJ7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A9BIJ7

No associated diseases with A9BIJ7

5 regional properties for A9BIJ7

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 51 - 62 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 22 - 567 IPR002300
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 610 - 752 IPR013155
domain Valyl-tRNA synthetase, tRNA-binding arm 820 - 879 IPR019499
domain Valyl tRNA synthetase, anticodon-binding domain 572 - 698 IPR033705

Functions

Description
EC Number 6.1.1.9 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
valine-tRNA ligase activity Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H(+).

1 GO annotations of biological process

Name Definition
valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. The valyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a valine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDIGKRYMPH ELENKWYKLW EENHSFEPKP GNGKFSIVIP PPNITGRIHI GHALNIVLQD
70 80 90 100 110 120
ISVRYNRMKG KETVWIPGED HAGIATQHVV EKYLLKEEGK RREDYTREEF LKITWDWANK
130 140 150 160 170 180
YRNHIREQIK ALAASVDWSR ERFTLDEGLN QAVRKVFVSL YNEGLIYKGK YIVNWCPSCG
190 200 210 220 230 240
TVLADDEVEH SEEKGKLWYI KYPLENTQNY VTVATTRPET MLGDTALAVN PSDERYKNLI
250 260 270 280 290 300
GETAILPIVG RKLKIIADPY VDTNFGTGVV KVTPAHDPND YQIGLRHDLE RIQIIDENAR
310 320 330 340 350 360
INENGGKYAG LDRYIARERI VEDLKKEGLL EKEEDYTHSV GHCYRCDTVI EPLLLDQWFV
370 380 390 400 410 420
KMKPLAEKAI QVVENDEIKF YPERWKKVYL NWMYEIRDWC ISRQLWWGHR IPVWYCQNCG
430 440 450 460 470 480
HVNVSVEDVK KCEKCGSTDL KQDEDVLDTW FSSALWPFST LGWPEETEDL KKYYPTDLLV
490 500 510 520 530 540
TGFDIIFFWV ARMIMMGEKF MGEKPFHDVY LHQLVRDKYG RKMSKSLGNG VDPLEVINEY
550 560 570 580 590 600
GTDPVRFTLS VLAAQGRDIK LDVGSFDAYR KFANKIWNAA RFVLLNMEDY EKTVLKDEDL
610 620 630 640 650 660
KIEDKWILTR LNSTILEISK DLEVYNYDQA ARKLYDFFWN ELCDWYIEAS KNRLNSIGKD
670 680 690 700 710 720
KLVVQNVILQ VFDSSLRLLH PFMPYISEEL WQKLPIEKDS ELLISAKWPE YNESNIYPEA
730 740 750 760 770 780
EKVFSKVMEL VSGIRNVKAE MDIPQTQEVD VKYKIVAKND DFIEKNKNLI EHLAFLINIT
790 800 810 820 830 840
QTEVKPAKSA TAYVDESVEV YIPLGDYIDI DTEKQRLTKK LEKLSKDIEL YNKKLSNKNF
850 860 870
VEKADPDVVE KTKEDLIESE KKYQKLQALL KEIS