A9B9E5

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Prochlorococcus marinus (strain MIT 9211)
KEGG Pathway
pmj:P9211_00511
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-45 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A9B9E5

Entry ID Method Resolution Chain Position Source
AF-A9B9E5-F1 Predicted AlphaFoldDB

No variants for A9B9E5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A9B9E5

No associated diseases with A9B9E5

4 regional properties for A9B9E5

Type Name Position InterPro Accession
domain DHHA1 domain 742 - 884 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 661 - 704 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 19 - 561 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 15 - 717 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTVEQLSPHS KSHPLTGEEI RTAFLHFFAE RGHQVLPSAS LVPDDPTVLL TIAGMLPFKP
70 80 90 100 110 120
VFLGHEERPS SRVVTSQKCI RTNDIENVGR TARHQTYFEM LGNFSFGDYF KKEAIQWAWE
130 140 150 160 170 180
LSTKTFGLDP KYLVVSIFRE DDDAYEIWRN IIGVNPDRII RMDEADNFWS SGPTGPCGPC
190 200 210 220 230 240
SELYYDFNPE LGNHCIDLED DTRFIEFYNL VFMEFNRDST GRLSSLSNCN IDTGMGLERM
250 260 270 280 290 300
AQILQKVPNN YETDLIYPLL EKVAYLVGVD YQKTDKKTRI SYKVIGDHIR ACVQLISDGV
310 320 330 340 350 360
SASNLGRGYI LRRLLRRIVR HGRLLGIPKP FLIDLGEVAI SLMKSTYPQL LERRDVILKE
370 380 390 400 410 420
LQREELRFLE TLERGERLLA DLLSNNPKEI SGEQAFELYD TYGFPLELTQ EIAEENSIEV
430 440 450 460 470 480
DLKAFEKAMQ RQRIRAKAAS TTIDLTLQDT LDKAVRELKP TNFKGYECLT ETSTVQAIFI
490 500 510 520 530 540
NGELAQEAQE NDVIQVALDI TPFYGESGGQ IGDTGILFKE SVTNCLIEID SVIRNNDVFV
550 560 570 580 590 600
HRGIVKNGRL QVGDIIQSQV HHINRRRAQI NHTATHLLQA SLKEIVGSEI SQAGSLVSFE
610 620 630 640 650 660
RLRFDFHCSS PVSSEELEKV EKKINLWISE SHSLVVKEMK IDDAKQAGAV AMFGEKYGTL
670 680 690 700 710 720
VRVVDVPGVS MELCGGTHVA NTADIGAFKI VGESGIAAGI RRIEAVAGPG VFDYFNARDS
730 740 750 760 770 780
VVRILSERFK VQSNEIVDRV IALQDEVKLL GKSLIKAQEE IAFAKTSALV SKATAIKSSH
790 800 810 820 830 840
YIIHRLDGVP SEALQSAAKV LVDQLGDCSA VLLAGTPTQS DPNKVILVAA FGAKTVAHGL
850 860 870 880
HAGKFLGPIA KMCGGGGGGR PNFAQAGGRD AKPLDKALDL AREQLMGALL