A9B660

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Herpetosiphon aurantiacus (strain ATCC 23779 / DSM 785 / 114-95)
KEGG Pathway
hau:Haur_3635
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

29-111 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A9B660

Entry ID Method Resolution Chain Position Source
AF-A9B660-F1 Predicted AlphaFoldDB

No variants for A9B660

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A9B660

No associated diseases with A9B660

4 regional properties for A9B660

Type Name Position InterPro Accession
domain DHHA1 domain 749 - 887 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 655 - 713 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 5 - 557 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 1 - 726 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKGSELRQRF LDYFARQGHA VVPSSSLIPA DNPTLLFTVA GMVQFNDVFL GRESRPYSRA
70 80 90 100 110 120
VSSQKCLRIS GKQNDLENVG PSPRHHTFFE MLGNFSFGDY FKKDAIRFAW EFLTQEIGLD
130 140 150 160 170 180
PKRMWVSIYE GDEQIPADEE AHDLWLAYMP AERILRFDAK DNLWSAGDVG PRGPCSEIHY
190 200 210 220 230 240
YIGDDPDNQV PEGVNSEDDT YMEIWNLVFM QYNRDENGVL TLLPKPSIDT GMSLERLAIV
250 260 270 280 290 300
KQGVFRSYET DLFTPIIHTV MELLGTGSDH YQANSSAYHV VADHSRSIAF MIADGLRPGN
310 320 330 340 350 360
EGRSYVLRRL VRRAAYFGQT IGFKAPFLAE TIATVIDMMG AAYPELRSKQ AYIAEVVTGE
370 380 390 400 410 420
EERFNKTLAG GLRQLEAMLP NQADKAVFSG ADAFKLYDTY GFPLDLTERI VAERGLTVDL
430 440 450 460 470 480
AGYEAELEAQ RARGRGAAQF KKGAVTERWA ERNLAPTSFT GYNELESWGH VLALEFDGEE
490 500 510 520 530 540
LGTVQRGQEV AFVLDRTPCY AESGGQMGDS GVLVGPHGTI VIDDVQKPVP GVFVHRGKVS
550 560 570 580 590 600
KGSVSLGEQV TVTVDAARRR DIVRNHTATH LLHRALRDTL GDHAEQKGSL VAPERLRFDF
610 620 630 640 650 660
NNQKGLSSEQ LQQIEDQVNA WIRADSKVEA AEMALPQARE LGAMALFGEK YGDVVRVVTV
670 680 690 700 710 720
GCGNASDHIH TNSEAPVCSR ELCGGVHVAR TGEIGFFKIV SEGSVASGVR RIEAVTGRAA
730 740 750 760 770 780
AEWVSQQAQL IRTLGDKLGA QPGKVEEKLD ALLLDQKARR DEIERLRGEI AAGQVDSLLA
790 800 810 820 830 840
QKIEQAGTPL VVARVEASDA DSFRRLGEQL RDKIGSGVVI LGTVIDGKPL LLAAATADQV
850 860 870 880
KAGRHAGNLV KALAAKVGGG GGGRADFAQA GGRDAAALDQ ALAEANGLL