A9AB64

PR
Gene name
serS
Protein name
Type-2 serine--tRNA ligase
Names
Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase
Species
Methanococcus maripaludis (strain C6 / ATCC BAA-1332)
KEGG Pathway
mmx:MmarC6_1776
EC number
6.1.1.11: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

82-152 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A9AB64

Entry ID Method Resolution Chain Position Source
AF-A9AB64-F1 Predicted AlphaFoldDB

No variants for A9AB64

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A9AB64

No associated diseases with A9AB64

2 regional properties for A9AB64

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 306 - 485 IPR002314
domain Serine-tRNA ligase type 2, tRNA-binding domain 1 - 162 IPR041293

Functions

Description
EC Number 6.1.1.11 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
serine-tRNA ligase activity Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser).
zinc ion binding Binding to a zinc ion (Zn).

3 GO annotations of biological process

Name Definition
selenocysteine biosynthetic process The chemical reactions and pathways resulting in the formation of selenocysteine, an essential component of glutathione peroxidase and some other proteins.
selenocysteinyl-tRNA(Sec) biosynthetic process The chemical reactions and pathways resulting in the formation of selenocysteinyl-tRNA(Sec). This process occurs through the following steps: a unique serine-tRNA with a UGA recognizing anticodon is first aminoacylated with serine; this is then phosphorylated by phosphoseryl-tRNA
seryl-tRNA aminoacylation The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. The seryl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a serine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRFKLDGRII FSKDVEEETQ KDIVEVLENG DIFLKGVPEG KENEASKIET YEFDGKDLKL
70 80 90 100 110 120
KMTSGTYTRA HEGIVRLKKP IMEKVGRKHQ IGIRDVAIDR YVVTITAEPS KVSELKGLKV
130 140 150 160 170 180
PECEVELEGE KINIVFENLG DGELKRNIID RAIKFVKNEL DKQDKDLTFE VCKIAPGTIV
190 200 210 220 230 240
SDYKAKREIT FDTDPTELAE PYGWVKRFPG RGQWFYTAPM AKLFRAFESL IIEECIDKIG
250 260 270 280 290 300
FDECLFPKLI PLDVMYKMRY LEGLPEGMYY VCPPKREPEM FQDFVNEMMI KKEIPIEKLK
310 320 330 340 350 360
TLLRDPAYVL APAQCEPFYT FFDHELVDVD HPSKFFDKSG WTYRWEGGGA KGLDRVNEFL
370 380 390 400 410 420
RGECVWMGTP EFVETVRDDT LKYAENLAEK LDLEYWTEVG DDPFYLEGRK TEARGIEFPD
430 440 450 460 470 480
VPKYEMRLWL PHIKEERKGV AVTSANIHGT HFVEGFGIKD YKERKVWTGC TGYGLTRWVI
490 500 510
GFLAQYGYNY DDWPELIQKK VGKLPEIPKL ITWP