A9A6M9

PR
Gene name
gap
Protein name
Glyceraldehyde-3-phosphate dehydrogenase
Names
GAPDH, NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase
Species
Methanococcus maripaludis (strain C6 / ATCC BAA-1332)
KEGG Pathway
mmx:MmarC6_0626
EC number
1.2.1.59: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

148-219 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A9A6M9

Entry ID Method Resolution Chain Position Source
AF-A9A6M9-F1 Predicted AlphaFoldDB

No variants for A9A6M9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A9A6M9

No associated diseases with A9A6M9

No regional properties for A9A6M9

Type Name Position InterPro Accession
No domain, repeats, and functional sites for A9A6M9

Functions

Description
EC Number 1.2.1.59 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

5 GO annotations of molecular function

Name Definition
4-hydroxy-tetrahydrodipicolinate reductase Catalysis of the reaction: (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+.
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+.
glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) activity Catalysis of the reaction: phosphate + NADP+ + glyceraldehyde-3-phosphate = NADPH + 3-phospho-D-glyceroyl-phosphate.
NAD binding Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.
NADP binding Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.

2 GO annotations of biological process

Name Definition
glycolytic process The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.
lysine biosynthetic process via diaminopimelate The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVNVLINGYG SIGKRVADAV AKQDDMKVIG VTKTKPDFEA RMAVEKGYKL FAAIPERKHL
70 80 90 100 110 120
FEEAGIPVEG TLDDIIEDAD IVVDGAPKKI GKANLENVYK KHGVKAIIQG GEKAGDAQDS
130 140 150 160 170 180
FNSLWSYNRC YGKDYIRLVS CNTTGLCRSM YAINSVADIL KARIVLIRRA ADPNDVKTGP
190 200 210 220 230 240
VNAIVPNPVS VPSHHGPDVV SVIPELDGKI MTSAVIVPTT LMHMHSIMVE TSGTNRDEII
250 260 270 280 290 300
DALAKTPRIL TLKASEGFDS TAKIIEYARD LGRSRYDLNE IAVWEESVNV VDNEVYMMQA
310 320 330
IHQESDVIPE NVDCIRAMLE MESDNLKSIE KTNKAMGLIK