A8YWA5
Gene name |
miaA |
Protein name |
tRNA dimethylallyltransferase |
Names |
Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase |
Species |
Lactobacillus helveticus (strain DPC 4571) |
KEGG Pathway |
lhe:lhv_1564 |
EC number |
2.5.1.75: Transferring alkyl or aryl groups, other than methyl groups |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A8YWA5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A8YWA5-F1 | Predicted | AlphaFoldDB |
No variants for A8YWA5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A8YWA5 | |||||
No associated diseases with A8YWA5
6 regional properties for A8YWA5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | DNA gyrase B subunit, C-terminal | 573 - 633 | IPR002288 |
| domain | Histidine kinase/HSP90-like ATPase | 39 - 183 | IPR003594 |
| domain | TOPRIM domain | 428 - 542 | IPR006171 |
| domain | DNA topoisomerase, type IIA, subunit B, domain 2 | 231 - 400 | IPR013506 |
| conserved_site | DNA topoisomerase, type IIA, conserved site | 432 - 440 | IPR018522 |
| domain | DNA gyrase subunit B, TOPRIM domain | 428 - 541 | IPR034160 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.5.1.75 | Transferring alkyl or aryl groups, other than methyl groups |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| tRNA dimethylallyltransferase activity | Catalysis of the reaction: dimethylallyl diphosphate + tRNA = diphosphate + tRNA containing 6-dimethylallyladenosine. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| tRNA processing | The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MQKVLAIVGP | TAIGKTDLAI | SLAKKLNGEI | VSGDSMQVYH | EVEVGTAKAT | KEEQAEVKHY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LVDTRSVFDE | YSVKDFVDEA | TEAINDIGEK | NKLPILAGGT | GFYVNALLNK | MQLGERKEED |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SGTSQKWEDY | LKQNGPQKLW | DILNEKDPEA | AKKIPVPNSR | RTMRALTVID | RTGKKFSQQQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KKIEPRYDYL | IIGLNSDRQE | IYRRINLRVD | RMMQKGMLEE | AKFIYQNRDK | EHQVLQAIAY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KEFFPYFKGE | KTLNECVEQL | KTASRRYAKR | QLTYFRNQLP | VNWFDPLNDP | DCEDKIIKNI |
| EAWKNE |