A8YUZ9

PR
Gene name
hisS
Protein name
Histidine--tRNA ligase
Names
Histidyl-tRNA synthetase, HisRS
Species
Lactobacillus helveticus (strain DPC 4571)
KEGG Pathway
lhe:lhv_1013
EC number
6.1.1.21: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

166-240 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A8YUZ9

Entry ID Method Resolution Chain Position Source
AF-A8YUZ9-F1 Predicted AlphaFoldDB

No variants for A8YUZ9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A8YUZ9

No associated diseases with A8YUZ9

4 regional properties for A8YUZ9

Type Name Position InterPro Accession
domain Anticodon-binding 335 - 417 IPR004154
domain Aminoacyl-tRNA synthetase, class II 20 - 319 IPR006195
domain Histidyl-anticodon-binding 331 - 416 IPR033656
domain Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain 8 - 320 IPR041715

Functions

Description
EC Number 6.1.1.21 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
histidine-tRNA ligase activity Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).

1 GO annotations of biological process

Name Definition
histidyl-tRNA aminoacylation The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. The histidyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3''-OH group of a histidine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRVQKPKGTV DILPEQSGSW QKVEETARNF FNRANYREIR TPSFENYEIF SRSSGDSSEI
70 80 90 100 110 120
VEKQMYDFND KGGRHIALRP EGTAGVVRAY VEDKMYAPEV VKPFNVFYME STFRYERPQA
130 140 150 160 170 180
GRQREFHQIG VESFGSSNPL ADVQTIMMGH DLLGELGVKN YQLHINTLGN EQVRKGYHDA
190 200 210 220 230 240
LVNYFTPVKD ELSEDSQRRL RDNPLRILDS KDDRDKKFLP DAPKIRDFLD DNSKANFESI
250 260 270 280 290 300
LKMLDQLGID YVIDDDLVRG LDYYTGVIFE FMVEDKSLWE SATTILGGGR YDHLVEEFNG
310 320 330 340 350 360
PETPAVGFGI GEERLMLVLE KQNPELFKNE GIDFFITNIG EGTAQKAIEI ARSLRKQGFE
370 380 390 400 410 420
ADFDVNQKKL KGQFKKADRE GAKYVITLGE KELANGVLNI KRLADGKTID LSLEDINDMN
KVMKELKD