A8YUW0

PR
Gene name
thyA
Protein name
Thymidylate synthase
Names
TS, TSase
Species
Lactobacillus helveticus (strain DPC 4571)
KEGG Pathway
lhe:lhv_0955
EC number
2.1.1.45: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-62 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A8YUW0

Entry ID Method Resolution Chain Position Source
AF-A8YUW0-F1 Predicted AlphaFoldDB

No variants for A8YUW0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A8YUW0

No associated diseases with A8YUW0

2 regional properties for A8YUW0

Type Name Position InterPro Accession
active_site Thymidylate synthase, active site 180 - 208 IPR020940
domain Thymidylate synthase/dCMP hydroxymethylase domain 7 - 318 IPR023451

Functions

Description
EC Number 2.1.1.45 Methyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

1 GO annotations of molecular function

Name Definition
thymidylate synthase activity Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = 7,8-dihydrofolate + thymidylate.

3 GO annotations of biological process

Name Definition
dTMP biosynthetic process The chemical reactions and pathways resulting in the formation of dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate).
dTTP biosynthetic process The chemical reactions and pathways resulting in the formation of dTTP, deoxyribosylthymine triphosphate.
methylation The process in which a methyl group is covalently attached to a molecule.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAILEQPYLD LLQKIMSEGH GKDDRTGTGT RSYFGAQMRF DLSQGFPLLT TKKVPFGLIK
70 80 90 100 110 120
SELLWFLRGD TNIRFLLEHN NHIWDEWAFK NWVNSSEYQG PDMTDFGLRS QSDPEFNKIY
130 140 150 160 170 180
QAEMKKFDQR ILDDEDFAKK YGNLGDVYGA QWRHWEKREG GFIDQIADVI KQIKETPDSR
190 200 210 220 230 240
RMIVTAWNPE DVPTSALPPC HVMFQFYVVD GKISVQLYQR SGDMFLGVPF NIASYSLLLN
250 260 270 280 290 300
LIARETGLQV GEFIHTLGDA HIYRNHLKQV EELLSRKPYD SPQLWLNPEK KNIADFEMKD
310
IKVVDYQHHG TIKAPVAV