A8XYX3

PR
Gene name
CBG20907
Protein name
Inactive cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1B
Names
Inactive cap1 2'O-ribose methyltransferase 1B, MTr1B
Species
Caenorhabditis briggsae
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-259 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A8XYX3

Entry ID Method Resolution Chain Position Source
AF-A8XYX3-F1 Predicted AlphaFoldDB

No variants for A8XYX3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A8XYX3

2 associated diseases with A8XYX3

Without disease ID

5 regional properties for A8XYX3

Type Name Position InterPro Accession
domain TolB, N-terminal 28 - 121 IPR007195
repeat WD40-like beta propeller 202 - 227 IPR011659-1
repeat WD40-like beta propeller 243 - 274 IPR011659-2
repeat WD40-like beta propeller 283 - 318 IPR011659-3
repeat WD40-like beta propeller 365 - 393 IPR011659-4

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
mRNA (nucleoside-2'-O-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + m7G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppRm-RNA. R may be guanosine or adenosine.
nucleic acid binding Binding to a nucleic acid.

3 GO annotations of biological process

Name Definition
7-methylguanosine mRNA capping Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript.
cap1 mRNA methylation Methylation of the ribose of the first nucleotide of a 5'-capped mRNA.
mRNA methylation The posttranscriptional addition of methyl groups to specific residues in an mRNA molecule.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MYVFVDRLSD SVSIPFVSKR AYRKRVNLDD DEDDFVDDPS PTEQKTKAEK KMERMGYKAG
70 80 90 100 110 120
EGLGKNKQGI QEPIAISFRE GKAGLGHEQW DDSTENKTVE ETVIWMTNID EGIRREICDK
130 140 150 160 170 180
LIKDDQWMVV RKEKKVIDDE TKFCSEKKLK DMLEAKNVFD SMSEKDIREA RTRANPYETI
190 200 210 220 230 240
GSAFFLNRSA MKTANMDKIY DWILSRENTG NNSFLLKNPL QEGTTAENVD RHEDLFYFAD
250 260 270 280 290 300
VCAGPGGFSE YMLWRKAFYN AKGFGFTLAG KDDFKLQKFT ASSAYFFETF YGTKKNGDVM
310 320 330 340 350 360
DPENIDSLEK LISEGTDGQG VHLMMADGAF SVQGQENIQE ILSKRLYLCQ LLVSLCIVRE
370 380 390 400 410 420
GGNFLCNLFD IFTPFSVGLI YLMRVCYDSI SLHKPHTSRP ANSERFVVCK GLRIECARVV
430 440 450 460 470 480
KEYLKRVNRK LDELKNKNSK DDVMELMPLD VIKSDEQFMK EIIEHNEVLA HRQTVYLQKY
490 500 510 520 530 540
KSFAKNQGQF DKDQGNLRDE CLKYWQVPNK QRPRGGDRGS HLRRGRMGNK FPEFSISMLQ
550 560 570 580 590 600
SKIPLNIPYE EYRFVALGAA SDPQLLIGTG DAVFIYRHGH FEQIDRDYAR IPENTILLVD
610 620 630 640 650 660
CAEEVKTDGS KIRISSDPHM IRIVDAAVLY GDNVSQLPYE ARMKAAQKFA LALKLTKKTI
670 680 690 700 710 720
QIGWGFRAKD ITPHQVCCAQ TYSLKELDEF QSNLIELKQR GEVIVLFKEG DRQFKTQSLR
730 740 750 760 770 780
LTRIIKQDWQ MGWSKSQQVP YVHSPLHQKE GSILEDQWKK REIHSSFWDS VILTNKDKQK
790 800 810 820 830 840
MTEMMQHGHN AVPSTIWSWK PCMRTEYGPY KIMNHPEAFD GKPTISAIKS QIAETDLSTQ
PSNYFY