A8XYX2

PR
Gene name
CBG20906
Protein name
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1A
Names
Cap1 2'O-ribose methyltransferase 1A, MTr1A
Species
Caenorhabditis briggsae
KEGG Pathway
EC number
2.1.1.57: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-236 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A8XYX2

Entry ID Method Resolution Chain Position Source
AF-A8XYX2-F1 Predicted AlphaFoldDB

No variants for A8XYX2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A8XYX2

No associated diseases with A8XYX2

3 regional properties for A8XYX2

Type Name Position InterPro Accession
domain G-patch domain 58 - 106 IPR000467
domain Ribosomal RNA methyltransferase, FtsJ domain 212 - 438 IPR002877
domain RrmJ-type ribose 2-O-methyltransferase domain 211 - 440 IPR025816

Functions

Description
EC Number 2.1.1.57 Methyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
mRNA (nucleoside-2'-O-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + m7G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppRm-RNA. R may be guanosine or adenosine.
nucleic acid binding Binding to a nucleic acid.

3 GO annotations of biological process

Name Definition
7-methylguanosine mRNA capping Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript.
cap1 mRNA methylation Methylation of the ribose of the first nucleotide of a 5'-capped mRNA.
mRNA methylation The posttranscriptional addition of methyl groups to specific residues in an mRNA molecule.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSERGDDDRT TSTINSLAKR RYQDNLDTFQ EERAGFQQKR PHAVDDEDED FETAAPPTKQ
70 80 90 100 110 120
KTKAEEMMER MGYKAGEGLG KNKQGIQEPV ALSTQRGKTG LGHEGAKAVA RDMNEQWDDS
130 140 150 160 170 180
TENKTVEETV IWMTDIDEGI RREICDKLIK DDQWMVVRKE KKVIDDETEF CSEKELKDMI
190 200 210 220 230 240
EAKNVFDSMS DKDLREARTR ANPYETIGSA FFQNRAAMKT ANMDKIYDWI LSRENTGNNS
250 260 270 280 290 300
FLLKNPLQEG TTAENVDRHE DLFYFADVCA GPGGFSEYML WRKAFYNAKG FGFTLAGKDD
310 320 330 340 350 360
FKLQKFTASS AYFFETFYGT KKNGDVMDPE NIDSLEKFIS EGTDGQGVHL MMADGGFSVE
370 380 390 400 410 420
GQENIQEILS KRLYLCQLLV SLCIVREGGN FFCKLFDIFT PFSVGLIYLM RVCYDSISLH
430 440 450 460 470 480
KPHTSRPANS ERYITCKGLR KEFAGVVKDY LKRVNRKLDE LKNKNSKDDV MELMPLDVIK
490 500 510 520 530 540
SDEQFMKEII EHNEVLAHRQ TVYLQKYKSF AKNQGQFDKD QGNLRDECLK YWQVPNKQRP
550 560 570 580 590 600
RGGDRGSRNG NQERLNPNVV LGKYTSKICG EAELGISFRG LGAASDPQLL IGTGDAVFIY
610 620 630 640 650 660
RHGHFEQIDR DYARIPENTI LLVDCAEEVK TDGSKIRISS DPHMIRIADA AVLYGDNVSQ
670 680 690 700 710 720
LPYEARMKAA QKFALALKLT KKTIQIGWGF RAKDITPHQV CCAQTYSLKE LDEFQSNLIE
730 740 750 760 770 780
LKQRGEVIVL FKEGDRQFKT QSLRLTRIIK QDWQMGWSKS QQVPYVHSPL HQKEGSILED
790 800 810 820 830 840
QWKKREIHSS FWDSVILTNK DKQKMTEMMQ HGHNAVPSTI WSWKPCMRTE YGPYKIMNHP
850 860 870
EAFDGKPTIS AIKSQIAETD LSTLRSKYTP LTAL