A8XY95
Gene name |
metr-1 (CBG20636) |
Protein name |
Probable methionine synthase |
Names |
5-methyltetrahydrofolate--homocysteine methyltransferase, Vitamin-B12 dependent methionine synthase, MS |
Species |
Caenorhabditis briggsae |
KEGG Pathway |
|
EC number |
2.1.1.13: Methyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A8XY95
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A8XY95-F1 | Predicted | AlphaFoldDB |
No variants for A8XY95
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A8XY95 | |||||
No associated diseases with A8XY95
6 regional properties for A8XY95
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Pterin-binding domain | 360 - 621 | IPR000489 |
| domain | Homocysteine-binding domain | 7 - 327 | IPR003726 |
| domain | Cobalamin (vitamin B12)-binding module, cap domain | 652 - 749 | IPR003759 |
| domain | Vitamin B12-dependent methionine synthase, activation domain | 927 - 1273 | IPR004223 |
| domain | Cobalamin (vitamin B12)-binding domain | 762 - 897 | IPR006158 |
| domain | Methionine synthase, B12-binding domain | 661 - 886 | IPR033706 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.1.1.13 | Methyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| cobalamin binding | Binding to cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. |
| methionine synthase activity | Catalysis of the reaction: (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine. |
| zinc ion binding | Binding to a zinc ion (Zn). |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| methionine biosynthetic process | The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. |
| methylation | The process in which a methyl group is covalently attached to a molecule. |
| pteridine-containing compound metabolic process | The chemical reactions and pathways involving any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTRSSLFKEL | ADIAKERIMI | IDGAMGTMIQ | REYMEEHDFR | GEILKDHDKP | LKGNNDLLSI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TRPDIIYKIH | KLYLEAGADF | IETNTFSGTT | IAQADYHCEH | LVHEINYQSA | LVARRACDDV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GAATGIRRYV | CGAIGPTNRT | LSISPSVEKP | DFRNVTFQEL | VKAYGDQARS | LIQGGVDVLL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VETVFDSANA | KAALFAIRTL | FEDEGVPEIP | VFLSGTIVDM | SGRTLSGQTG | EAFLVSTKQG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KPIAVGLNCA | LGAKDMRQFV | QNMSLWSDTL | ILCYPNAGLP | NALGGYDETP | EEMAEVLREF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AQDGLVNIIG | GCCGTTPDHI | NAMYKAVQGI | SPRVPPADPH | AGKMLLSGLE | PSIVGPETNF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VNIGERCNVA | GSRRFCNLIK | NENYDTAIDV | ARVQVDSGAQ | ILDVNMDDGL | LDGPYAMSKF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LRLISSEPDV | AKIPVCIDSS | DFDVIIAGLE | STQGKCVVNS | ISLKEGEEKF | KERARIVKRY |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GAAVVVMAFD | EEGQAAETER | KFEICERSYR | ILTEEVGFNP | NDIIFDANIL | TIATGMDEHA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| NYGMYFIEAT | RMIRENLPGA | HVSGGVSNIS | FSFRGMEAIR | EAMHSVFLFY | AIKAGMDMGI |
| 610 | 620 | 630 | 640 | 650 | 660 |
| VNAGALPVYE | DIDKPLLQLL | EDLLFNRDPE | ATEKLLVAAQ | EMKKDGKKAD | TKTDEWRNTS |
| 670 | 680 | 690 | 700 | 710 | 720 |
| VEERLKFALV | KGIDQFVVAD | TEEARQNTEK | YPRPLNVIER | PLMDGMAVVG | ELFGAGKMFL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| PQVIKSARVM | KKAVAHLLPF | MDAERQANIE | KMGLDEDESP | YQGTVVIATV | KGDVHDIGKN |
| 790 | 800 | 810 | 820 | 830 | 840 |
| IVAVVLGCNN | FKVVDLGVMT | PCENIIKAAI | EEKADFIGLS | GLITPSLDEM | VHVAKEMNRV |
| 850 | 860 | 870 | 880 | 890 | 900 |
| GLKIPLLIGG | ATTSKTHTAV | KIAPRYPHPV | VHCLDASKSV | VVCSSLSDMT | VRDAFLQDLN |
| 910 | 920 | 930 | 940 | 950 | 960 |
| EDYEDVRTKM | CLVSYLNHFF | ITEHYESLKD | RRFVALGKTR | EKKFNIDWNK | FSPVKPSFIG |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| RREFQNFDFK | ELIPYIDWKP | FFDVWQLRGK | YPNRSYPKIF | DDADVGGEAK | RVFDDAQTWL |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| KKLIDEKVLT | ANAVVSFLPA | ASEGDDIHVY | DPETGNKLDT | FYGLRQQSGR | EHDQSHFCLS |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| DFIRPLKIGV | PDDYLGLFAC | TAGLGAEEYC | KVLEENHDDY | ASIMVKALAD | RLAEAYAEYL |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| HKEVRVNLWG | YSTNEQLTET | DLLSIKYEGI | RPACGYPSQP | DHTEKRTLWK | LLEAEKNGIV |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| LTEHLAMLPA | ASVSGLYFAN | PQSQYFAVGK | IDEDQVAFIY | VRSKNVTDYA | ARKNVPKEEV |
| 1270 | |||||
| ERWLSPIIGY | ELD |