A8XW88
Gene name |
kin-1 |
Protein name |
cAMP-dependent protein kinase catalytic subunit |
Names |
PKA C |
Species |
Caenorhabditis briggsae |
KEGG Pathway |
cbr:CBG_19814 |
EC number |
2.7.11.11: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
192-212 (Activation loop from InterPro)
Target domain |
52-305 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for A8XW88
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A8XW88-F1 | Predicted | AlphaFoldDB |
No variants for A8XW88
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A8XW88 | |||||
No associated diseases with A8XW88
5 regional properties for A8XW88
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Dehydrogenase, E1 component | 489 - 817 | IPR001017 |
| domain | 2-oxoacid dehydrogenase acyltransferase, catalytic domain | 103 - 335 | IPR001078 |
| domain | Transketolase-like, pyrimidine-binding domain | 879 - 1080 | IPR005475 |
| domain | Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal | 1084 - 1230 | IPR031717 |
| domain | 2-oxoglutarate dehydrogenase E1 component, N-terminal domain | 5 - 37 | IPR032106 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.11 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| AMP-activated protein kinase activity | Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of AMP. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| cAMP-dependent protein kinase activity | cAMP-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| protein kinase A signaling | A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLKFLKPKSS | DEGSSKDNKS | AASLKEFLDK | AREDFKQRWE | NPAQNTACLD | DFDRIKTLGT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GSFGRVMLVK | HKQSGNYYAM | KILDKQKVVK | LKQVEHTLNE | KRILQAIDFP | FLVNMTFSFK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DNSNLYMVLE | FISGGEMFSH | LRRIGRFSEP | HSRFYAAQIV | LAFEYLHSLD | LIYRDLKPEN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LLIDSTGYLK | ITDFGFAKRV | KGRTWTLCGT | PEYLAPEIIL | SKGYNKAVDW | WALGVLIYEM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AAGYPPFFAD | QPIQIEKIVS | GKVKFPSHFS | NELKDLLKNL | LQVDLTKRYG | NLKNGVADIK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NHKWFGSTDW | IAIYQRKIKP | PSFSNGEPKG | RLFEALYARV | DGPADTRHFV | EEVQEPTQFV |
| 370 | |||||
| IASTCQLPEL | FEDF |