A8XL25

PR
Gene name
crn-1
Protein name
Flap endonuclease 1
Names
FEN-1, Cell death-related nuclease 1, Flap structure-specific endonuclease 1
Species
Caenorhabditis briggsae
KEGG Pathway
cbr:CBG_14945
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

308-382 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A8XL25

Entry ID Method Resolution Chain Position Source
AF-A8XL25-F1 Predicted AlphaFoldDB

No variants for A8XL25

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A8XL25

No associated diseases with A8XL25

6 regional properties for A8XL25

Type Name Position InterPro Accession
domain 5'-3' exonuclease 29 - 304 IPR002421
domain XPG, N-terminal 1 - 107 IPR006085
domain XPG-I domain 146 - 233 IPR006086
conserved_site Helix-hairpin-helix motif, class 2 220 - 253 IPR008918
conserved_site XPG conserved site 79 - 93 IPR019974-1
conserved_site XPG conserved site 149 - 163 IPR019974-2

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
  • Nucleus, nucleoplasm
  • Mitochondrion
  • Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

6 GO annotations of molecular function

Name Definition
5'-3' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end.
5'-flap endonuclease activity Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
magnesium ion binding Binding to a magnesium (Mg) ion.
manganese ion binding Binding to a manganese ion (Mn).
RNA-DNA hybrid ribonuclease activity Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters.

3 GO annotations of biological process

Name Definition
apoptotic DNA fragmentation The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments.
base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase.
DNA replication, removal of RNA primer Removal of the Okazaki RNA primer from the lagging strand of replicating DNA, by a combination of the actions of DNA polymerase, DNA helicase and an endonuclease.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGIKGLSQVI ADHAPSAIKV QEIKAFFGRK VAIDASMCLY QFLIAIRQDG SQMQSEDGET
70 80 90 100 110 120
TSHLMGMFYR TIRMIDNGIK PVYVFDGKPP DMKSGELEKR TERRAEAEKA LTEAKEKGDA
130 140 150 160 170 180
KEAEKFERRL VKVTKQQNEE VKQLLGLMGI PVVEAPCEAE AQCANLVKAG KVYGTATEDM
190 200 210 220 230 240
DALTFGSCVL LRHLLAPEAK KIPIKEFHLA RVLEEMQLTK DQFIDLCILL GCDYCGTIRG
250 260 270 280 290 300
IGPKKAVELI KQHKNIETVL ENIDQTKYPP PADWPYKRAR ELFHEPEVMK CDEVELTWKD
310 320 330 340 350 360
PDVEGIVKFM CGEKNFSEDR IRSAMVRMQK SRNAGTQGRI DSFFTVSSQV KCVTVAKRKA
370 380
QEEAEKMKKG GKKSGPPKKK AK