A8XJW8

PR
Gene name
cst-1 (CBG14395)
Protein name
Serine/threonine-protein kinase cst-1
Names
Species
Caenorhabditis briggsae
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-56 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

171-194 (Activation loop from InterPro)

Target domain

35-286 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for A8XJW8

Entry ID Method Resolution Chain Position Source
AF-A8XJW8-F1 Predicted AlphaFoldDB

No variants for A8XJW8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A8XJW8

No associated diseases with A8XJW8

4 regional properties for A8XJW8

Type Name Position InterPro Accession
domain Protein kinase domain 35 - 286 IPR000719
domain SARAH domain 443 - 490 IPR011524
binding_site Protein kinase, ATP binding site 41 - 65 IPR017441
domain Mst1 SARAH domain 443 - 490 IPR024205

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

6 GO annotations of biological process

Name Definition
determination of adult lifespan The pathways that regulate the duration of the adult phase of the life-cycle of an animal.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
muscle cell development The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate.
protein phosphorylation The process of introducing a phosphate group on to a protein.
protein tetramerization The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits.
regulation of MAPK cascade Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPPSTDSSRR NSEEGFSDGF KLDSSALNKP PEEVFDIVGK LGEGSYGSVH KAIHKESGHV
70 80 90 100 110 120
LAIKKVPVDT DLQEIIKEIS IMQQCKSKYV VKYYGSYFKN SDLWIVMEYC GAGSISDIMR
130 140 150 160 170 180
ARRKPLSEKE ISAVLRDTLK GLQYLHDLKK IHRDIKAGNI LLNTDGIAKL ADFGVAGQLT
190 200 210 220 230 240
DTMAKRNTVI GTPFWMAPEV IEEIGYDTKA DIWSLGITAI EMAEGRPPYS DIHPMRAIFM
250 260 270 280 290 300
IPTKPPPTFK KPEEWSSEFN DFIRCCLIKK PEERKTALRL CEHTFIENAP GCDVLQAMIL
310 320 330 340 350 360
DAQEKVLLGQ APVAVAGADA TLLSEGMSTM IDGGDATLVQ YKDNYVTAQS LRSQMESLKI
370 380 390 400 410 420
GGEIPKSAYG SSRNNGSPRV QPPGHTASAC DPSNNPPFAE EGTGPNFQIG TSESSYKDAS
430 440 450 460 470 480
YNMMNTEAEY ENRFQRAVCD GDFEFLRNIT LDELIRRKES LDSEMEEEIR ELQRRYKTKR
490
QPILDVIEIK KRLN