A8XJQ6

PR
Gene name
CBG14305
Protein name
cAMP-dependent protein kinase, catalytic subunit-like
Names
Species
Caenorhabditis briggsae
KEGG Pathway
EC number
2.7.11.11: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-81 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A8XJQ6

Entry ID Method Resolution Chain Position Source
AF-A8XJQ6-F1 Predicted AlphaFoldDB

No variants for A8XJQ6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A8XJQ6

No associated diseases with A8XJQ6

5 regional properties for A8XJQ6

Type Name Position InterPro Accession
domain TolB, N-terminal 22 - 128 IPR007195
repeat WD40-like beta propeller 242 - 271 IPR011659-1
repeat WD40-like beta propeller 282 - 316 IPR011659-2
repeat WD40-like beta propeller 325 - 349 IPR011659-3
repeat WD40-like beta propeller 376 - 400 IPR011659-4

Functions

Description
EC Number 2.7.11.11 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cAMP-dependent protein kinase complex An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer.

4 GO annotations of molecular function

Name Definition
AMP-activated protein kinase activity Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of AMP.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cAMP-dependent protein kinase activity cAMP-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.

2 GO annotations of biological process

Name Definition
peptidyl-serine phosphorylation The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSSSTSSVES VEDESCSNEC SASFTFDTNN NSRGDQQVDE LAEETHMKLS ITPTRESFSL
70 80 90 100 110 120
SQLERIVTIG KGTFGRVELA RDKISGAHYA LKVLNIRRVV DMRQTQHVHN EKRVLLQLKH
130 140 150 160 170 180
PFIVKMYASE KDSNNLYMIM EFVPGGEMFS YLRASRSFSN SMARFYASEI VCALEYIHSL
190 200 210 220 230 240
GIVYRDLKPE NLMLSKEGHI KMADFGFAKE LRDRTYTICG TPDYLAPESL ARTGHNKGVD
250 260 270 280 290 300
WWALGILIYE MMVGKPPFRG KTTAEIYDSI IEHKLKFPRS FNLAAKDLVK KLLEVDRTQR
310 320 330 340 350 360
IGCMKNGTQD VKDHKWFEKV NWDDTLHLRV EVKKLIGIFL IPIFQPPIVP TLYHPGDTGN
370 380
FDDYEEDTTG GPLCSQRERD LFAEW