A8X6H1

PR
Gene name
egl-4
Protein name
cGMP-dependent protein kinase egl-4
Names
Egg-laying defective protein 4
Species
Caenorhabditis briggsae
KEGG Pathway
EC number
2.7.11.12: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

54-173 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

579-601 (Activation loop from InterPro)

Target domain

438-698 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for A8X6H1

Entry ID Method Resolution Chain Position Source
AF-A8X6H1-F1 Predicted AlphaFoldDB

No variants for A8X6H1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A8X6H1

No associated diseases with A8X6H1

4 regional properties for A8X6H1

Type Name Position InterPro Accession
domain Translation elongation factor P/YeiP, central 68 - 128 IPR001059
domain Translation elongation factor, KOW-like 4 - 61 IPR013185
conserved_site Translation elongation factor P/YeiP, conserved site 152 - 171 IPR013852
domain Elongation factor P, C-terminal 131 - 186 IPR015365

Functions

Description
EC Number 2.7.11.12 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • In resting AWC sensory neurons, localizes in cytoplasm
  • Prolonged exposure to attractive odorants sensed by AWC neurons results in nuclear translocation
  • Nuclear translocation is required for the adaptation to prolonged odor exposure and is controlled by G(o)-alpha subunit protein goa-1
  • Localization is regulated by cGMP levels: high cGMP levels result in cytoplasmic localization whereas low cGMP levels result in nuclear localization
  • Nuclear localization in AWC neurons is dependent on age-1
  • In addition, an intact sensory cilia structure is required for cytoplasmic localization in resting AWC neurons
  • In resting AWB sensory neurons, constitutive nuclear localization is dependent on goa-1
  • In resting ASH sensory neurons, localizes in both cytoplasm and nucleus
  • Cytoplasmic localization is important for negative regulation of quinine sensitivity in ASH neurons
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cGMP binding Binding to cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate).
cGMP-dependent protein kinase activity cGMP dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein.
metal ion binding Binding to a metal ion.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.

2 GO annotations of biological process

Name Definition
chemotaxis The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
protein phosphorylation The process of introducing a phosphate group on to a protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MYGSSRHHLD SFSSNDGNAF LVQVGSRTFE AHELQKLIPQ LEEAISRKDA QLRQQQSIVE
70 80 90 100 110 120
GHIKRISELE GEVTTLQREC DKLRSVLEQK AQSAASPGQP PSPSPRTDQL GNDLQQKAVF
130 140 150 160 170 180
PADGTQQRAK KIAVSAEPTN FENKPATLQH YNKTVAAKQM IRDAVQKNDF LKQLAKEQII
190 200 210 220 230 240
ELVNCMYEMR ARAGQWVIQE GEPGDRLFVV AEGELQVSRE GATLGKMRAG TVMGELAILY
250 260 270 280 290 300
NCTRTASVQA LTDVQLWVLD RSVFQMITQR LGMERHSQII NFLSKVSIFA NLTEDRISKI
310 320 330 340 350 360
ADVMDQDYYD GGHYILRQGE KGDAFFVINS GQVKVTQQIE GEKEAREIRI LNQGDFFGER
370 380 390 400 410 420
ALLGDEVRTA NIIAQAPGVE VLTLDRESFT KLIGDLDTLR KDYGDKERVA TLVREPPSPV
430 440 450 460 470 480
KIVDDFREEF ANVTLKNVKR LATLGVGGFG RVELVCVNGD KSKTYALKAL KKKHIVDTRQ
490 500 510 520 530 540
QEHIFAERNI MMETSTDWIV KLYKTFRDQK FVYMLLEVCL GGELWTTLRD RGHFDDYTAR
550 560 570 580 590 600
FYVACVLEGL EYLHRKNIVY RDLKPENCLL ANSGYLKLVD FGFAKKLASG RKTWTFCGTP
610 620 630 640 650 660
EYVSPEIILN KGHDQAADYW ALGIYICELM LGRPPFQASD PMKTYTLILK GVDALEIPNR
670 680 690 700 710 720
RIGKTATALV KKLCRDNPGE RLGSGSGGVN DIRKHRWFMG FDWEGLRTKT LKPPILPKVN
730 740
NPADVTNFDN YPPDNDVPPD EFSGWDEGF