A8X2R1

PR
Gene name
CBG06643
Protein name
L-2-hydroxyglutarate dehydrogenase, mitochondrial
Names
Species
Caenorhabditis briggsae
KEGG Pathway
EC number
1.1.99.2: With other acceptors
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-50 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A8X2R1

Entry ID Method Resolution Chain Position Source
AF-A8X2R1-F1 Predicted AlphaFoldDB

No variants for A8X2R1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A8X2R1

No associated diseases with A8X2R1

4 regional properties for A8X2R1

Type Name Position InterPro Accession
domain C2 domain 378 - 493 IPR000008
domain Pleckstrin homology domain 519 - 624 IPR001849
domain MUN domain 837 - 1302 IPR010439
domain Munc13 homology 1 933 - 1113 IPR014770

Functions

Description
EC Number 1.1.99.2 With other acceptors
Subcellular Localization
  • Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

2 GO annotations of molecular function

Name Definition
(S)-2-hydroxy-acid oxidase activity Catalysis of the reaction: (S)-2-hydroxy-acid + O2 = 2-oxo acid + hydrogen peroxide.
2-hydroxyglutarate dehydrogenase activity Catalysis of the reaction: (S)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLTRKTFHAF RSISGPPKKS VELPKYDLVI VGGGIVGCAT ARQLLIEKPN LKIALVEKEK
70 80 90 100 110 120
ELAVHQSGHN SGVIHAGIYY TPGSLKAKLC VEGLDLSYEF FDKEKIPYKK TGKLIVAVEQ
130 140 150 160 170 180
EEVPRLDALF ARAQTNGCRD IEMIDSKRIT DIEPHCKGLK ALWSPHTGIV DWGYVTKKFG
190 200 210 220 230 240
EDFEKRGGKI YTSYPLEKIE DNLKDSNYPI RVSSDPSYAD FETKNLITCA GLQSDRVAAL
250 260 270 280 290 300
SGCSTDPKIV PFRGEYLLLK PEKRHLVKTN IYPVPDPRFP FLGVHFTPRM NGDIWLGPNA
310 320 330 340 350 360
VLAYKREGYS YFSISPSDLL ESLSYSGMQK LVKKHFTFGI KELYRGIWIA AQVKQLQRFI
370 380 390 400 410 420
PELKYSDVTR GPSGVRAQAM DSAGNLVDDF VFDSGTGKLS SLIMHVRNAP SPAATSSLAI
430
AKMITSEAIT RFKL