A8X0C4

PR
Gene name
par-4
Protein name
Serine/threonine-protein kinase par-4
Names
Species
Caenorhabditis briggsae
KEGG Pathway
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-211 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

341-366 (Activation loop from InterPro)

Target domain

197-460 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for A8X0C4

Entry ID Method Resolution Chain Position Source
AF-A8X0C4-F1 Predicted AlphaFoldDB

No variants for A8X0C4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A8X0C4

No associated diseases with A8X0C4

4 regional properties for A8X0C4

Type Name Position InterPro Accession
domain Protein kinase domain 197 - 460 IPR000719
active_site Serine/threonine-protein kinase, active site 320 - 332 IPR008271
binding_site Protein kinase, ATP binding site 203 - 226 IPR017441
domain Serine/Threonine kinase LKB1, catalytic domain 203 - 460 IPR039154

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm, cell cortex
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cell cortex The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
centrosome A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
spindle pole Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
protein kinase activator activity Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

6 GO annotations of biological process

Name Definition
establishment of cell polarity The specification and formation of anisotropic intracellular organization or cell growth patterns.
glucose homeostasis Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
mitotic cell cycle Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of cell growth Any process that modulates the frequency, rate, extent or direction of cell growth.
regulation of cytokinesis Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEGPSSSSVP TASDAPSKYL LPSDSDDGIA TSSAANVGAR NHVTNTEKME KEKKPSPMVL
70 80 90 100 110 120
NVDPDYDYDE EDGGSCEEDQ RGPPAPISRE IVDGAIARRS RDRQISPGVK MSIGNYDDME
130 140 150 160 170 180
DDDEEAETPE EQKQRFLASM KRIRNQPQEA FDPPEDTEAM REFINRQVND AMMFNRDNHI
190 200 210 220 230 240
DYSPVNKPKE AKIIEGYLWG GIIGTGSYGK VKEVIDIYTI TRRAAKIMKY EKLRKIPNGW
250 260 270 280 290 300
DNIRSEMSIL RRLNHRNIVK LIEVFNLPEK GKVYMIFEYC IGSVQNLIDM EPAHRLSIGE
310 320 330 340 350 360
SHAIFLELCH GLNYLHSKRV SHKDIKPGNL LLSIDMTVKI CDFGVAEQIC LFQSDGRCTK
370 380 390 400 410 420
VNGTPKFQPP ECVYGNHEYF DGYKVDMWSA GVTLYNMVSG KYPFEQQVLL RLYESIGTNP
430 440 450 460 470 480
VEMPTNVELS KDLQDIIKRL LDKDFNTRPN ISDVMQHPWF QTGFPEDQGL GRIMERMRTG
490 500 510 520 530 540
DRPFTMYPSL QAMYDGAGSE VILDEDGNEL VLPPPDLVKR GLKFFLELKI LENLPGTLSL
550 560 570 580 590 600
SSFPGFQTLE KRPGDGPPPS SDSGVVAAPD SASGDPLRRP SSRSMPTSAP PRPPSGAVEV
610 620 630 640
VEAVAAPEAV VEDPVVEEAP AQQQEAPDRR RRGKRSLFSC IFRSRTDSS