A8WZ92

PR
Gene name
spe-8
Protein name
Spermatocyte protein spe-8
Names
Defective spermatogenesis protein spe-8
Species
Caenorhabditis briggsae
KEGG Pathway
EC number
2.7.10.2: Protein-tyrosine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-180 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A8WZ92

Entry ID Method Resolution Chain Position Source
AF-A8WZ92-F1 Predicted AlphaFoldDB

No variants for A8WZ92

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A8WZ92

No associated diseases with A8WZ92

6 regional properties for A8WZ92

Type Name Position InterPro Accession
domain Protein kinase domain 140 - 450 IPR000719
domain SH2 domain 117 - 208 IPR000980
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 243 - 438 IPR001245
active_site Tyrosine-protein kinase, active site 305 - 317 IPR008266
domain Tyrosine-protein kinase, catalytic domain 222 - 440 IPR020635
domain Fes/Fps/Fer, SH2 domain 114 - 199 IPR035849

Functions

Description
EC Number 2.7.10.2 Protein-tyrosine kinases
Subcellular Localization
  • Cell membrane; Peripheral membrane protein
  • Cytoplasm
  • Localizes mainly in the cytoplasm in stage I spermatocytes and at the cell membrane in stage II spermatocytes and in spermatids
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
extrinsic component of cytoplasmic side of plasma membrane The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
non-membrane spanning protein tyrosine kinase activity Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein.
protein tyrosine kinase activity Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
signaling receptor binding Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

4 GO annotations of biological process

Name Definition
cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
spermatogenesis The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.
transmembrane receptor protein tyrosine kinase signaling pathway The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSGVELQPES TQSEEKEEPK TAATTISSTE ETKTENPNVA LDNLAKTPIQ LILQPTPQTP
70 80 90 100 110 120
AKTPETPRIQ KINNLKKSAS FDSKNQPEDS KTPKQRDQLI EVPSDEVGRV ENNIDNLPFY
130 140 150 160 170 180
HGFMGRTECE SMLSNHGDFL IRMTEVGRRV AYVISVRWHY QNSHVLVKRT KTKKLYWTKK
190 200 210 220 230 240
YAFKSICELI AYHKLNQIPF YDNMTLICGL ARHEWQLNNE QVTLNKKLGE GQFGEVHKGK
250 260 270 280 290 300
LKPNVIKFYG VCTMKEPIMI VMEFCDGSSL EDVLLSKESK VSSEDKILYL FHAACGIDYL
310 320 330 340 350 360
HGKHVIHRDI AARNCLLNSK KVLKISDFGL SVKGVAIKER KGGCLPVKYM APETLKKGFY
370 380 390 400 410 420
STASDIYSYG ALVYEVYTDG KTPFESCGLR GNELRKAIIG KSVILTIDVE CPEFVKAIFE
430 440 450 460 470
QSRLYDTEQR ISSKRIIEIF KEEAGMHELD ATGLFGRIGS FFSRVRRQKE AEPSVPILT