A8WXF6

SS
Gene name
unc-43
Protein name
Calcium/calmodulin-dependent protein kinase type II
Names
CaM kinase II, Uncoordinated protein 43
Species
Caenorhabditis briggsae
KEGG Pathway
cbr:CBG04391
EC number
2.7.11.17: Protein-serine/threonine kinases
Protein Class

Descriptions

CaMKII is one of the most important transducers of Ca2+signals in a variety of cell types and is highly conserved across animal species. Ca2+/CaM removes an autoinhibitory regulatory segment located C-terminal to the kinase domain which releases the catalytic activity of the enzyme and makes accessible a regulatory residue.

Autoinhibitory domains (AIDs)

273-320 (Regulatory segment) SS

Target domain

12-269 (Protein kinase domain)

Relief mechanism

Partner binding

Assay

Accessory elements

154-176 (Activation loop from InterPro)

Target domain

12-269 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for A8WXF6

Entry ID Method Resolution Chain Position Source
AF-A8WXF6-F1 Predicted AlphaFoldDB

No variants for A8WXF6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A8WXF6

No associated diseases with A8WXF6

4 regional properties for A8WXF6

Type Name Position InterPro Accession
domain Protein kinase domain 12 - 269 IPR000719
active_site Serine/threonine-protein kinase, active site 130 - 142 IPR008271
domain Calcium/calmodulin-dependent protein kinase II, association-domain 400 - 524 IPR013543
binding_site Protein kinase, ATP binding site 18 - 41 IPR017441

Functions

Description
EC Number 2.7.11.17 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
  • Cell projection, axon
  • Perikaryon
  • Localizes at or near the Golgi apparatus
  • Localizes to post-synaptic regions and is enriched in punctate structures in axons of AWC neurons where it co-localizes with tir-1
  • Localization is regulated by tir-1
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
neuron projection A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
perikaryon The portion of the cell soma (neuronal cell body) that excludes the nucleus.

6 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
calmodulin binding Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
calmodulin-dependent protein kinase activity Calmodulin-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate.
metal ion binding Binding to a metal ion.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine/tyrosine kinase activity Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MMNACTKFSD NYDVKEELGK GAFSVVRRCV HKTTGLEFAA KIINTKKLSA RDFQKLEREA
70 80 90 100 110 120
RICRKLQHPN IVRLHDSIQE ESFHYLVFDL VTGGELFEDI VAREFYSEAD ASHCIQQILE
130 140 150 160 170 180
SIAYCHSNGV VHRDLKPENL LLASKAKGAA VKLADFGLAI EVNDSEAWHG FAGTPGYLSP
190 200 210 220 230 240
EVLKKDPYSK PVDIWACGVI LYILLVGYPP FWDEDQHRLY AQIKAGAYDY PSPEWDTVTP
250 260 270 280 290 300
EAKSLIDSML TVNPKKRITA DQALKVPWIC NRERVASAIH RQDTVDCLKK FNARRKLKAA
310 320 330 340 350 360
ISAVKMVTRM SGVLRTSDST GSVASNGSTT HDTSQIAGTS SQPTSPAAEG AILTTMIATR
370 380 390 400 410 420
NLSNLGRNLL NKKEQGPPST IKESSESSQT IDDNDSEKAQ KQDIVRVTQT LLDAISCKDF
430 440 450 460 470 480
DTYTRLCDTS MTCFEPEALG NLIEGIEFHR FYFDGNRKNQ VHTTMLNPNV HIIGEDAACV
490 500 510 520 530
AYVKLTQFLD RNGEAHTRQS QESRVWSKKQ GRWLCVHVHR STQPSTNTTV SEF