A8WUG4

PR
Gene name
pkc-3
Protein name
Protein kinase C-like 3
Names
Atypical protein kinase C-3, aPKC3
Species
Caenorhabditis briggsae
KEGG Pathway
cbr:CBG_02381
EC number
2.7.11.13: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

159-234 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A8WUG4

Entry ID Method Resolution Chain Position Source
AF-A8WUG4-F1 Predicted AlphaFoldDB

No variants for A8WUG4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A8WUG4

No associated diseases with A8WUG4

11 regional properties for A8WUG4

Type Name Position InterPro Accession
domain PB1 domain 12 - 95 IPR000270
domain Protein kinase domain 253 - 522 IPR000719
domain AGC-kinase, C-terminal 524 - 595 IPR000961
domain Protein kinase C-like, phorbol ester/diacylglycerol-binding domain 127 - 179 IPR002219
active_site Serine/threonine-protein kinase, active site 373 - 385 IPR008271
binding_site Protein kinase, ATP binding site 259 - 286 IPR017441
domain Protein kinase, C-terminal 544 - 585 IPR017892
domain Diacylglycerol/phorbol-ester binding 125 - 139 IPR020454-1
domain Diacylglycerol/phorbol-ester binding 141 - 150 IPR020454-2
domain Diacylglycerol/phorbol-ester binding 154 - 165 IPR020454-3
domain Diacylglycerol/phorbol-ester binding 166 - 178 IPR020454-4

Functions

Description
EC Number 2.7.11.13 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
  • Cytoplasm, cytoskeleton
  • Targeted and anchored at the apical surface (villi) of intestinal and pharyngeal cells, and in proximity with the cortical actin cytoskeleton that lies under the plasma membrane
  • Tightly bound to organelles/cytoskeleton in six of the seven developmental stages
  • Accumulation in cytoplasm is restricted to L1 larvae and adults
  • Colocalized with par-3 at the anterior cortex of the 1-cell embryo (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
apical plasma membrane The region of the plasma membrane located at the apical end of the cell.
cortical actin cytoskeleton The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

6 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
calcium-dependent protein kinase C activity Calcium-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein.
metal ion binding Binding to a metal ion.
protein domain specific binding Binding to a specific domain of a protein.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

12 GO annotations of biological process

Name Definition
cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
defense response to fungus Reactions triggered in response to the presence of a fungus that act to protect the cell or organism.
embryo development ending in birth or egg hatching The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.
establishment or maintenance of cell polarity Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.
gastrulation A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.
gonad development The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones.
gonadal mesoderm development The process whose specific outcome is the progression of the gonadal mesoderm over time, from its formation to the mature structure. The gonadal mesoderm is the middle layer of the three primary germ layers of the embryo which will go on to form the gonads of the organism.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
peptidyl-serine phosphorylation The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
protein localization Any process in which a protein is transported to, or maintained in, a specific location.
response to wounding Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
single fertilization The union of male and female gametes to form a zygote.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSSPTSVEED GDIKLKTRFH GQVVVLYARP PLILDDFFAL LRDACKQHAK QDITVKWIDE
70 80 90 100 110 120
DGDPISIDSQ MELDEAVRCL NVSQEAELNI HVFVGKPELP GLPCQGEDKT VYRRGARRWK
130 140 150 160 170 180
KIYLYNGHRF QGKRLNRRIQ CFICHDYIWG IGRQGFRCVD CRLCVHKKCH RHVRTHCGQT
190 200 210 220 230 240
PQGPNVPVAP SSGVGSLRGG RLDTSSSTTR SGGGIDNGAF HEHEIESPGS AKDMSRSTNG
250 260 270 280 290 300
NGASKWAVSL NDFRLLTVIG RGSYAKVVQA EHIATRQIYA IKIIKKEMFN EDEDIDWVQT
310 320 330 340 350 360
EKSVFEAASN YPFLVGLHSC FQTESRLFFV IEFVPGGDLM FHMQQQRRLP EEHARFYSGE
370 380 390 400 410 420
IILALHFLHS RGIIYRDLKL DNVLIDAEGH IKLTDYGMCK ENINAGDLTS TFCGTPNYIA
430 440 450 460 470 480
PEILRGDEYG FSVDWWALGV LMFEMMAGRS PFDIVGMQNS EENTEDYLFQ IILERQIRIP
490 500 510 520 530 540
RSLSVRASNI LKGFLNKDPS QRLGCKLDIN DGLNDMKEHD FFRGFIDWEA LEQKAVAPPY
550 560 570 580 590
HPAVESDRDL THFDHQFTDE PPQLSPDNSA VIARIDQSEF DGFEYVNPLQ MSREDSV