A8WQY8
Gene name |
cif-1 |
Protein name |
COP9/Signalosome and eIF3 complex-shared subunit 1 |
Names |
COP9 signalosome complex subunit 7, Signalosome subunit 7, Eukaryotic translation initiation factor 3 subunit M, eIF3m |
Species |
Caenorhabditis briggsae |
KEGG Pathway |
cbr:CBG_01738 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A8WQY8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A8WQY8-F1 | Predicted | AlphaFoldDB |
No variants for A8WQY8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A8WQY8 | |||||
No associated diseases with A8WQY8
1 regional properties for A8WQY8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Proteasome component (PCI) domain | 188 - 369 | IPR000717 |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| COP9 signalosome | A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome. |
| eukaryotic 43S preinitiation complex | A protein complex composed of the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound methionyl-initiator methionine tRNA. |
| eukaryotic 48S preinitiation complex | A protein complex composed of the small ribosomal subunit, eIF3, eIF1A, methionyl-initiatior methionine and a capped mRNA. The complex is initially positioned at the 5'-end of the capped mRNA. |
| eukaryotic translation initiation factor 3 complex | A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs. |
| eukaryotic translation initiation factor 3 complex, eIF3m | An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3m. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| translation initiation factor activity | Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| cell cycle switching | The process in which a cell switches cell cycle mode. |
| cytoplasmic translational initiation | The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA. |
| formation of cytoplasmic translation initiation complex | Joining of the large subunit, with release of IF2/eIF2 and IF3/eIF3. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site. |
| negative regulation of ubiquitin protein ligase activity | Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin protein ligase activity. |
| oogenesis | The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster. |
| protein deneddylation | The removal of a ubiquitin-like protein of the NEDD8 type from a protein. |
| regulation of oogenesis | Any process that modulates the frequency, rate or extent of oogenesis. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MADTRELPVF | AYIDDIKQLQ | ELRQYLNKHE | SVKLDPTGPA | ETAKNLVEIC | STLHVLPLWS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QDVDLVLNSI | SSLIVVVPGE | KCEPVVDAFI | KNVSPKFYKG | IGWGSHAGIA | VRVLSNLYKG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YSNFHTVQEK | IFMALVDMCA | EARLIGELEC | NLETLHDRFN | TWQTPVEGQR | EILRAVHRAL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LVDQRADQAA | KVMTALLGTY | TEKDAATARD | DAMECVRTAV | VDPKSFSFDH | LERLSAVKAL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KSSDPLMFTA | LELFISGTLK | DYQQFVAKNP | KFVTDYLKVD | EVILLKKIRL | LTLMSLAEEK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NEIKLDELAK | QLDIHADETL | EEFVIDAIQV | NAISGKINEM | ANTLIVSSYQ | HRRFGSDQWV |
| 370 | 380 | ||||
| LLEKRLKVLI | ANLKQTHNNV | HEVNQRIEAL |