A8WPF0

PR
Gene name
sdhb-1
Protein name
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Names
Iron-sulfur subunit of complex II, Ip
Species
Caenorhabditis briggsae
KEGG Pathway
EC number
1.3.5.1: With a quinone or related compound as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-66 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A8WPF0

Entry ID Method Resolution Chain Position Source
AF-A8WPF0-F1 Predicted AlphaFoldDB

No variants for A8WPF0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A8WPF0

No associated diseases with A8WPF0

5 regional properties for A8WPF0

Type Name Position InterPro Accession
domain 2Fe-2S ferredoxin-type iron-sulfur binding domain 43 - 131 IPR001041
binding_site 2Fe-2S ferredoxin, iron-sulphur binding site 91 - 99 IPR006058
domain 4Fe-4S ferredoxin-type, iron-sulphur binding domain 174 - 204 IPR017896
conserved_site 4Fe-4S ferredoxin, iron-sulphur binding, conserved site 184 - 195 IPR017900
domain Succinate dehydogenase/fumarate reductase N-terminal 39 - 144 IPR025192

Functions

Description
EC Number 1.3.5.1 With a quinone or related compound as acceptor
Subcellular Localization
  • Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial membrane Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain.

7 GO annotations of molecular function

Name Definition
2 iron, 2 sulfur cluster binding Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands.
3 iron, 4 sulfur cluster binding Binding to a 3 iron, 4 sulfur (3Fe-4S) cluster; this cluster consists of three iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. It is essentially a 4Fe-4S cluster with one iron missing.
4 iron, 4 sulfur cluster binding Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
electron transfer activity Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.
metal ion binding Binding to a metal ion.
succinate dehydrogenase (ubiquinone) activity Catalysis of the reaction: succinate + ubiquinone = fumarate + ubiquinol.
ubiquinone binding Binding to ubiquinone, a quinone derivative with a tail of isoprene units.

3 GO annotations of biological process

Name Definition
aerobic respiration The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor.
respiratory electron transport chain A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.
tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLARSALFVH SAELAANAAR AASGAAAAQP KKTGNRIKTF EIYRFNPEAP GAKPTIQKFD
70 80 90 100 110 120
VDLDQCGTMI LDALIKIKNE VDPTLTFRRS CREGICGSCA MNIGGENTLA CICKIDADTS
130 140 150 160 170 180
KSTKIYPLPH MFVVKDLVPD MNLFYAQYAS IQPWIQKKTP LTLGEKQMHQ SVAERDRLDG
190 200 210 220 230 240
LYECILCACC STSCPSYWWN ADKYLGPAVL MQAYRWVIDS RDDYAQERLH RMHDSFSAFK
250 260 270 280
CHTIMNCTKT CPKHLNPAKA IGEIKSLLTG FKSKPAAEPS AF