A8QD31

PR
Gene name
ERB1
Protein name
Ribosome biogenesis protein ERB1
Names
Eukaryotic ribosome biogenesis protein 1
Species
Malassezia globosa (strain ATCC MYA-4612 / CBS 7966) (Dandruff-associated fungus)
KEGG Pathway
mgl:MGL_4099
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

54-241 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A8QD31

Entry ID Method Resolution Chain Position Source
AF-A8QD31-F1 Predicted AlphaFoldDB

No variants for A8QD31

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A8QD31

No associated diseases with A8QD31

6 regional properties for A8QD31

Type Name Position InterPro Accession
repeat WD40 repeat 493 - 549 IPR001680-1
repeat WD40 repeat 683 - 723 IPR001680-2
repeat WD40 repeat 726 - 765 IPR001680-3
repeat WD40 repeat 769 - 808 IPR001680-4
repeat WD40 repeat 820 - 864 IPR001680-5
domain BOP1, N-terminal domain 244 - 501 IPR012953

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
  • Nucleus, nucleoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
PeBoW complex A protein complex that is involved in coordinating ribosome biogenesis with cell cycle progression. In human, it is composed of Pes1, Bop1, and WDR12; in Saccharomyces the proteins are known as Nop7p, Erb1 and Ytm1 respectively.
preribosome, large subunit precursor A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit.

2 GO annotations of molecular function

Name Definition
large ribosomal subunit rRNA binding Binding to large ribosomal subunit RNA (LSU rRNA), a constituent of the large ribosomal subunit. In S. cerevisiae, this is the 25S rRNA.
ribonucleoprotein complex binding Binding to a complex of RNA and protein.

2 GO annotations of biological process

Name Definition
maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Any process involved in the maturation of an rRNA molecule originally produced as part of a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.
maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAVDKGRRPV PPERRAQGRK RAEPGDVTIR ETRTRPVHTP EPEPELLAKD GILELEDDDD
70 80 90 100 110 120
NDDDDDDDDD DKSNHHDGAP KNEDDMEAFP ELVSGKDKDD DGDEDEEEDD EDEDEDASDD
130 140 150 160 170 180
EAFDSDDLEN WDEEADAKYG DADLSDDDDV KEGDAALERM IARARVKPDE SERTTNKLGI
190 200 210 220 230 240
DTGVAARFYD ESRNDDGSKR GRVVQSHVTG MPKVEYPPIE PEYDSDSSTE DVPNRIGQVP
250 260 270 280 290 300
LSWYDDLPHI GYDINGRRVL RPAQGDELDK FLDSVEGEGD GWFSAHDKTS GQDVKLTDEE
310 320 330 340 350 360
LDIIQRLERA QIPVEAYDPY EPATDWFTQH QQTTPLTARP EPKRRFVPSK WEHKKIMKIV
370 380 390 400 410 420
RAIRQGRIVA HAPGRERPAF YNLWSDADEA RADHPMHMPA PKLPLPSHVE SYNPPAEYLF
430 440 450 460 470 480
GDDEKAEWEA AEPEDRKLPF LPAKYAALRL VPGYDQALHE RFQRCLDLYM APRMRRKRLD
490 500 510 520 530 540
IDDPDQLLPK LPAPRDLRPF PTHTDVVYAH APWRIRTVSI DPSGAWLLTG PDDGHVRLWD
550 560 570 580 590 600
AALGRCVATW DMNAGVARAD RSPVYCVQWC PNRTFGIAAA VSVGRVTLLA PPQCGKTMYE
610 620 630 640 650 660
ASLAHLTTPH AAEDAATAQW TRASEADRAA GVCVRIDVRN NKHASLVPKY VRWHARGDYF
670 680 690 700 710 720
ATVSPEAAGE AVLIHQVSKH RSQAPFRRTR RAGNSAMAVQ CVCFHPSRPW LFVATQRYVR
730 740 750 760 770 780
VYDLVQQSLV KTLQPGVRWI SSLDVHPSGD HVIIGSYDRR VLWFDLDLSE RPYKALRYHS
790 800 810 820 830 840
RAVRAVAYHP RFPLFASAAD DGTVHVYHGT VYSDLLQNAL LVPLKILRGH AVQDALGVLS
850 860
IAWHPTLPWL VSAGADGDAR LWTP