A8Q8J2

PR
Gene name
Bm1_46190
Protein name
Ubiquitin-fold modifier-conjugating enzyme 1
Names
Ufm1-conjugating enzyme 1
Species
Brugia malayi (Filarial nematode worm)
KEGG Pathway
bmy:BM_BM2685
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-52 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A8Q8J2

Entry ID Method Resolution Chain Position Source
AF-A8Q8J2-F1 Predicted AlphaFoldDB

No variants for A8Q8J2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A8Q8J2

No associated diseases with A8Q8J2

17 regional properties for A8Q8J2

Type Name Position InterPro Accession
repeat HAT (Half-A-TPR) repeat 289 - 321 IPR003107-1
repeat HAT (Half-A-TPR) repeat 323 - 355 IPR003107-2
repeat HAT (Half-A-TPR) repeat 384 - 416 IPR003107-3
repeat HAT (Half-A-TPR) repeat 417 - 446 IPR003107-4
repeat HAT (Half-A-TPR) repeat 447 - 476 IPR003107-5
repeat HAT (Half-A-TPR) repeat 554 - 586 IPR003107-6
repeat HAT (Half-A-TPR) repeat 588 - 620 IPR003107-7
repeat HAT (Half-A-TPR) repeat 622 - 654 IPR003107-8
repeat HAT (Half-A-TPR) repeat 656 - 687 IPR003107-9
repeat HAT (Half-A-TPR) repeat 689 - 721 IPR003107-10
repeat HAT (Half-A-TPR) repeat 723 - 755 IPR003107-11
repeat HAT (Half-A-TPR) repeat 757 - 789 IPR003107-12
repeat HAT (Half-A-TPR) repeat 791 - 823 IPR003107-13
domain PRP1 splicing factor, N-terminal 13 - 169 IPR010491
repeat Tetratricopeptide repeat 709 - 742 IPR019734-1
repeat Tetratricopeptide repeat 743 - 776 IPR019734-2
repeat Tetratricopeptide repeat 841 - 874 IPR019734-3

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
ubiquitin conjugating enzyme binding Binding to a ubiquitin conjugating enzyme, any of the E2 proteins.
UFM1 conjugating enzyme activity Isoenergetic transfer of UFM1 from one protein to another via the reaction X-UFM1 + Y -> Y-UFM1 + X, where both the X-UFM1 and Y-UFM1 linkages are thioester bonds between the C-terminal amino acid of UFM1 and a sulfhydryl side group of a cysteine residue.

1 GO annotations of biological process

Name Definition
protein ufmylation Covalent attachment of the ubiquitin-like protein UFM1 to another protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MELSESTKKA LKAIPLMRTK AGPRDGDSWV QRLKEEYEAL IAFINNNKAA DLDWFRLESN
70 80 90 100 110 120
SDGTRWFGKC WHYHNMLRYE FDVEFDIPVT YPTTAPEIAL PELDGKTAKM YRGGRICLSD
130 140 150 160
HFKPLWARNV PKFGIAQAFS LGLGPWLAVE VPDLVDRGMI QPKTA