A8NU66

PR
Gene name
LOS1 (CC1G_12568)
Protein name
Exportin-T
Names
Exportin(tRNA), Karyopherin-beta, tRNA exportin
Species
Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003) (Inky cap fungus) (Hormographiella aspergillata)
KEGG Pathway
cci:CC1G_12568
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

65-136 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A8NU66

Entry ID Method Resolution Chain Position Source
AF-A8NU66-F1 Predicted AlphaFoldDB

No variants for A8NU66

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A8NU66

No associated diseases with A8NU66

2 regional properties for A8NU66

Type Name Position InterPro Accession
domain Exportin-1/Importin-beta-like 113 - 282 IPR013598
domain Exportin-T, C-terminal domain 370 - 1060 IPR045546

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm
  • Shuttles between the nucleus and the cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
small GTPase binding Binding to a small monomeric GTPase.
tRNA binding Binding to a transfer RNA.

2 GO annotations of biological process

Name Definition
tRNA processing The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group.
tRNA re-export from nucleus The directed movement from the nucleus to the cytoplasm of a tRNA that was previously exported to the cytoplasm and then imported back into the nucleus. The processes of primary tRNA export and secondary export (re-export) can be distinguished because in organisms in which tRNA splicing occurs in the cytoplasm, the export of a mature tRNA must occur by re-export.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDQEIERVVQ AIAIASEPSQ STLFQEALNY IQGIQENANE TWRLALQIFV ATNGDQGRKY
70 80 90 100 110 120
PPQARFWALR VLEEFLENKF DPLDPETFQT LQQAMMSYIQ SEYVQGPAEA NAPFIRNKFS
130 140 150 160 170 180
HTLTLLFLCT YIDQWPSFFT DLFSLIQPSS QSSSTGLNRH ISLLFFHLVL EISGEVADQM
190 200 210 220 230 240
IKTARTWSAV RHARDGRVRD AVRERDAARI NEAVLTIVAT NVERMNALKE GDGDSQELGN
250 260 270 280 290 300
SIELVDWGIR TFGSYVGWID INLTVTPTTV PLLFKLLADS SLPIRLATSV ALLRIVAKGL
310 320 330 340 350 360
KEPADKLQLF KVLSLGQVLD ALESKTAKQQ RERGDDVDEG EESYREALGK LLNVYGLELT
370 380 390 400 410 420
KLVEDAPTDD IRSDASAALV DLQPVTLRFL ADDYDDTAST VFPLLQAVLG SYKRSRKVSS
430 440 450 460 470 480
GPIDDQKRSF LSALLQVILK KMKWDEEAEP DDVDDDDNGE FEKMRKELRT FMDAILTIDQ
490 500 510 520 530 540
DLVTDEVRKL ALQTISAYQS GTSLKWNDAE LGVYLVYIFG EINKSGGKGR AAFCQTPAVI
550 560 570 580 590 600
DKDKRKVTDY SEFPLTSHGE MLLALVQSGI VSYPNRTVSL QFFETVTRYA DFFKVRKECI
610 620 630 640 650 660
LPALEAMIDK RGLHNENQQF RIRLYYLFYK FIRESRHEIP SQIALTIINS LPDLLSINVQ
670 680 690 700 710 720
LSEPEDPESD PLTEAVKSPV FESQLYLFET IGILTSTLSK DTEEQGNLLL SIVKPFMEEL
730 740 750 760 770 780
LANLQLFRAG SQDLVPVVKV HHIIMALGNI SKGFPDHPAS TTSENYMAPS FKVFAEIAQA
790 800 810 820 830 840
ILVCLEAMNV IKPIRDATRF AFARILATAG PTVTGYIPPL MNHLLAHFEP SELVDFMNFI
850 860 870 880 890 900
SLLIHKLQKD MFEVLDKLIA PLHSHITAIL SQAASGTDEL RWQIETKKAY LNLLVVILNA
910 920 930 940 950 960
RLEGIFTSER NSASFEALLG SLLRIVEDVS DPPSQKLALT FFGRCVTVWG QPAGSPNPEL
970 980 990 1000 1010 1020
GGNLPGFERF IYEQIVPTAF GVVALPSFNP KDGQALMVIH EVASLLQTVC KTRGSEAYDY
1030 1040 1050 1060
FLSAFLPSKG WPAEMALDFT TKLRDLDSKN FRKYFTELIR ASRSS