A8NR45

PR
Gene name
ACU-7
Protein name
Isocitrate lyase
Names
ICL, Isocitrase, Isocitratase, Methylisocitrate lyase, MICA, Threo-D(S)-isocitrate glyoxylate-lyase
Species
Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003) (Inky cap fungus) (Hormographiella aspergillata)
KEGG Pathway
cci:CC1G_07122
EC number
4.1.3.1: Oxo-acid-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

65-174 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A8NR45

Entry ID Method Resolution Chain Position Source
AF-A8NR45-F1 Predicted AlphaFoldDB

No variants for A8NR45

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A8NR45

No associated diseases with A8NR45

2 regional properties for A8NR45

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 42 - 52 IPR001412
domain RNA-binding S4 domain 357 - 419 IPR002942

Functions

Description
EC Number 4.1.3.1 Oxo-acid-lyases
Subcellular Localization
  • Glyoxysome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
glyoxysome A specialized form of peroxisome that contains the enzymes of the glyoxylate pathway. The glyoxysome is found in some plant cells, notably the cells of germinating seeds.

3 GO annotations of molecular function

Name Definition
isocitrate lyase activity Catalysis of the reaction: isocitrate = glyoxylate + succinate.
metal ion binding Binding to a metal ion.
methylisocitrate lyase activity Catalysis of the reaction: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate.

2 GO annotations of biological process

Name Definition
glyoxylate cycle A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate.
tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSSERAQFAA EVAEVERWWK SPRFARVNRP YTAADVVSKR GTIKINYPSD VQGKKLWKLL
70 80 90 100 110 120
SEHAKNGTPS HTYGALDPVQ VTQMAKYLET VYVSGWQSSS TASSSNEPGP DLADYPSNTV
130 140 150 160 170 180
PNKVEHLFMA QLFHDRKQRE ARSRMSDAEL ANTPVIDYLR PIVADADTGH GGLTAVMKLT
190 200 210 220 230 240
KMFVEKGAAG IHIEDQAPGT KKCGHMAGKV LVPIQEHINR LVAIRLQYDI MGVENLVVAR
250 260 270 280 290 300
TDSEAATLIT SNIDDRDHPF IQGSTNPSLP PLNNVMVEAE AQGKTGDQLQ AIEDGWIKAA
310 320 330 340 350 360
NLQLFPQALA QALANEGASR STVEKLVARV SRLSWPQAVA VAQKEFGLKQ VPYWNWDAPR
370 380 390 400 410 420
TREGYYRYQG GTECAIHRAN AFAPYADLLW METKKPILAQ AKEFAAGVHA VHPGQWLAYN
430 440 450 460 470 480
LSPSFNWEAA GLNAQDMQAY VWELGKLGFV WQFITLAGLH SNAYISDLFA QNFAKTGMKA
490 500 510 520 530
YVELVQSRER EIGCDVLTHQ KWSGADYADS LIKTVTGGVS STAAMGAGVT ESQFTSKL