Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A8MVJ9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A8MVJ9-F1 | Predicted | AlphaFoldDB |
No variants for A8MVJ9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A8MVJ9 | |||||
No associated diseases with A8MVJ9
1 regional properties for A8MVJ9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Spider toxin CSTX, Knottin scaffold conserved site | 48 - 74 | IPR011142 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| histone binding | Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription. |
| poly-ADP-D-ribose binding | Binding to polymeric ADP-D-ribose, a polymer that is composed of poly-ADP-D-ribose units linked through 1,2-glycosidic bonds at the ribose ring. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to DNA damage stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. |
| peptidyl-serine ADP-ribosylation | The transfer, from NAD, of ADP-ribose to peptidyl-serine to form peptidyl-O-(ADP-ribosyl)-L-serine. |
| regulation of protein ADP-ribosylation | Any process that modulates the frequency, rate or extent of protein ADP-ribosylation. Protein ADP-ribosylation is the transfer, from NAD, of ADP-ribose to protein amino acids. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVGGGWKRRP | GAGAGPQCEK | TVDVKKSKFC | EADVSSDLRK | EVENHYTLSL | PEDFYHFWKF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| CEELDSEKPA | DPLSASLGLQ | LVDPYNILAG | KHKMKKKSTV | PNFNLHWRFY | YDPPEFQTII |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IRDKLSATWG | ISDRDSPDEL | PVYVGINEAK | KNCIIVPNGD | NVFAAVKLYL | MKKLKEVTDK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KKTNLFKNVD | EKLTETAREL | GYSLEQRTMK | MKQRDKKVVT | KTFHGTGLVP | PVDKNVVGYR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ELPETDADLK | RICKTIVEAA | SDDERRKAFA | PIQEMMTFVQ | FANDECDYGM | GLELGMDLFC |
| 310 | 320 | 330 | 340 | ||
| YGSHYFHKVA | GQLLPLAYNL | LKRNLFAEIM | KDHLANRRKE | NIDQFAA |