AiPD: Autoinhibited Protein Database

A8MV24

Gene name	C17orf98
Protein name	Uncharacterized protein C17orf98
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:388381
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

20-95 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

20-95 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for A8MV24

Entry ID	Method	Resolution	Chain	Position	Source
AF-A8MV24-F1	Predicted				AlphaFoldDB

167 variants for A8MV24

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs748862711 CA8526417	2	A>V		No	ClinGen ExAC gnomAD
CA8526415 rs747606930	3	Y>C		No	ExAC TOPMed gnomAD ClinGen
rs781022421 CA8526413	4	L>P		No	ClinGen ExAC gnomAD
CA398780966 rs750179754	4	L>V		No	ExAC TOPMed gnomAD ClinGen
CA8526411 rs201466719	6	E>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8526412 rs757056522	6	E>Q		No	ExAC gnomAD ClinGen
rs1451228715 CA398780927	7	C>R		No	TOPMed gnomAD ClinGen
CA398780916 rs1280868459	8	R>G		No	ClinGen TOPMed
TCGA novel	8	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA398780892 rs1346955260	10	R>L		No	gnomAD ClinGen
CA398780840 rs1218350616	14	G>A		No	ClinGen TOPMed
rs1187664347 CA398780801	17	L>S		No	ClinGen gnomAD
CA8526407 rs766483222 CA398780784	18	D>E		No	ExAC TOPMed gnomAD ClinGen
CA398780786 rs1211455826	18	D>G		No	ClinGen TOPMed
TCGA novel	18	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	19	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8526405 rs773702400	19	G>R		No	ExAC gnomAD ClinGen
TCGA novel	19	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs773702400 CA8526406	19	G>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
TCGA novel	20	V>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs762275873 CA398780778	20	V>L		No	ClinGen ExAC gnomAD
rs762275873 CA8526403	20	V>M		No	ClinGen ExAC gnomAD
rs528140278 CA290323352	23	S>G		No	Ensembl ClinGen
rs1166691794 CA398780757	23	S>R		No	gnomAD ClinGen
rs1390841446 CA398780749	25	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	gnomAD ClinGen NCI-TCGA
rs748725064 CA8526400	26	A>D		No	ClinGen ExAC gnomAD
TCGA novel	27	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1470625610 CA398780727	28	A>V		No	TOPMed ClinGen
CA8526397 rs745463786	29	Y>N		No	ClinGen ExAC gnomAD
rs373358342 CA8526395	30	G>A		No	ESP ExAC TOPMed gnomAD ClinGen
CA290323311 rs866750911	31	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	Ensembl ClinGen NCI-TCGA
CA290323308 rs1018607904	31	R>H		No	ClinGen TOPMed
CA398780714 rs866750911	31	R>S		No	ClinGen Ensembl
rs1342849116 CA398780710	32	S>P		No	TOPMed gnomAD ClinGen
rs1028367126 CA290323304	33	R>W		No	Ensembl ClinGen
rs369883104 CA290323300	34	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ESP ClinGen NCI-TCGA
CA398780629 rs1567683427	37	W>R		No	Ensembl ClinGen
rs1243140132 CA398780618	37	W>S		No	gnomAD ClinGen
TCGA novel	38	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8526394 rs746825476	38	S>W		No	ClinGen ExAC gnomAD
CA8526392 rs758405695	39	A>V		No	ExAC gnomAD ClinGen
CA8526391 rs766541161	41	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA8526390 rs766541161	41	P>Q		No	ExAC TOPMed gnomAD ClinGen
rs766541161 CA398780539	41	P>R		No	ClinGen ExAC TOPMed gnomAD
rs1409881463 CA398780529	42	P>S		No	ClinGen gnomAD
CA398780512 rs1371788553	43	Y>C		No	ClinGen gnomAD
CA290323274 rs975403556	43	Y>H		No	gnomAD ClinGen
rs375513531 CA398780500	44	N>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA8526386 rs373474691	44	N>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs201194773 CA8526387	44	N>S		No	1000Genomes ExAC TOPMed gnomAD ClinGen
rs375513531 CA8526388	44	N>Y		No	ESP ExAC TOPMed gnomAD ClinGen
CA8526384 rs764504486	45	A>S		No	ClinGen ExAC gnomAD
CA290323235 rs764504486	45	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ExAC gnomAD ClinGen NCI-TCGA
TCGA novel	45	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA290323222 rs1685888	46	Q>H		No	Ensembl ClinGen
rs763572126 CA398780459	46	Q>P		No	ClinGen ExAC TOPMed gnomAD
rs763572126 CA8526383	46	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs1685889 CA290323212	47	Q>E		No	ClinGen Ensembl
CA8526382 rs61752602	47	Q>R		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
TCGA novel	48	D>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1221061151 CA398780442	48	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	TOPMed ClinGen NCI-TCGA
rs1221061151 CA398780440	48	D>Y		No	ClinGen TOPMed
rs374779578 CA8526380	49	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs1276701815 CA398780434	49	Y>H		No	ClinGen gnomAD
CA8526379 rs745411971	50	H>P		No	ClinGen ExAC TOPMed gnomAD
rs1290009610 CA398780422	50	H>Q		No	gnomAD ClinGen
rs371239248 CA8526378	51	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1414154416 CA398780416	51	A>V		No	gnomAD ClinGen
TCGA novel	52	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8526377 rs770615199	53	S>R		No	ExAC gnomAD ClinGen
rs1278080154 CA398780401	54	Y>D		No	ClinGen gnomAD
CA290323184 rs573653158	55	F>L		No	Ensembl ClinGen
CA398780387 rs1351627337	56	Q>*		No	gnomAD ClinGen
rs7210156 VAR_044022 CA8526374	61	P>L		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
TCGA novel	63	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8526373 rs758257845	63	L>I		No	ExAC gnomAD ClinGen
TCGA novel	64	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs748063679 CA398780268	65	R>G		No	ExAC TOPMed gnomAD ClinGen
TCGA novel	65	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	66	K>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs778722822 CA8526371	67	T>S		No	ClinGen ExAC gnomAD
CA398780238 rs1380262273	67	T>S		No	gnomAD ClinGen
rs1472825993 CA398780210	69	Q>E		No	TOPMed gnomAD ClinGen
rs750554801 CA8526369	69	Q>H		No	ExAC TOPMed gnomAD ClinGen
CA290323157 rs1045842305	69	Q>L		No	TOPMed gnomAD ClinGen
CA398780204 rs1045842305	69	Q>R		No	ClinGen TOPMed gnomAD
TCGA novel	70	D>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA398779489 rs1178189060	71	H>L		No	ClinGen gnomAD
rs1359648743 CA398779496	71	H>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	gnomAD ClinGen NCI-TCGA
rs1470552333 CA398779454	73	G>D		No	ClinGen TOPMed
CA8526344 rs765740178	73	G>S		No	ExAC TOPMed gnomAD ClinGen
rs760097894 CA8526343	74	T>I		No	ExAC TOPMed gnomAD ClinGen
TCGA novel	75	G>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8526342 rs753337257	75	G>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	76	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA290321643 rs766611751	80	I>M		No	ClinGen Ensembl
rs765821049 CA8526341	80	I>T		No	ExAC gnomAD ClinGen
CA8526338 rs771647726	81	V>A		No	ExAC gnomAD ClinGen
rs367883766 CA8526339	81	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA8526340 rs367883766	81	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs371240095 CA290321632	82	D>N		No	gnomAD ClinGen
CA398779312 rs1306285368	83	Y>H		No	ClinGen TOPMed gnomAD
rs1306285368 CA398779313	83	Y>N		No	TOPMed gnomAD ClinGen
rs761647745 CA8526337	84	I>L		No	ClinGen ExAC gnomAD
rs1052001311 CA290321623	84	I>T		No	Ensembl ClinGen
rs1567682254 CA398779272	85	H>Q		No	ClinGen Ensembl
CA8526335 rs768711064	86	I>M		No	ClinGen ExAC TOPMed gnomAD
rs774054791 CA8526336	86	I>V		No	ClinGen ExAC gnomAD
rs374929993 CA398779247	87	F>L		No	ESP ExAC TOPMed gnomAD ClinGen
CA398779244 rs1395205002	88	G>R		No	ClinGen TOPMed gnomAD
TCGA novel	90	G>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA398779195 rs1304394051	91	Q>H		No	gnomAD ClinGen
TCGA novel	92	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	92	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA398779185 rs1460348510	92	R>S		No	ClinGen gnomAD
rs370386866 CA8526332	93	Y>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA8526331 rs747079575	94	L>H		No	ExAC gnomAD ClinGen
rs778032171 CA398779156	95	N>D		No	ExAC gnomAD ClinGen
rs1182559579 CA398779151	95	N>K		No	gnomAD ClinGen
CA398779154 rs1382977640	95	N>S		No	gnomAD ClinGen
CA8526330 rs778032171	95	N>Y		No	ClinGen ExAC gnomAD
rs753098821 CA8526327	101	G>E		No	ClinGen ExAC gnomAD
TCGA novel	101	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	102	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	103	G>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs374049509 CA8526326	103	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	105	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	105	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA398778792 rs1387886244	107	Q>R		No	TOPMed ClinGen
rs200340108 CA8526307	111	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA398778730 rs1170084994	112	H>Y		No	TOPMed gnomAD ClinGen
CA8526306 rs780517847	114	H>R		No	ExAC TOPMed gnomAD ClinGen
TCGA novel	115	Y>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1357312261 CA398778651	117	A>G		No	ClinGen gnomAD
rs1236581522 CA398778625	119	L>M		No	gnomAD ClinGen
CA8526305 TCGA novel rs756621447	120	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC TOPMed gnomAD NCI-TCGA
CA8526303 rs369060210	121	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA8526304 rs749944360	121	P>S		No	ExAC gnomAD ClinGen
CA398778588 rs749944360	121	P>T		No	ClinGen ExAC gnomAD
CA398778571 rs1322303806	122	I>T		No	gnomAD ClinGen
CA8526299 rs762818252	123	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ExAC TOPMed gnomAD ClinGen NCI-TCGA
rs1286797505 CA398778545	124	G>E		No	gnomAD ClinGen
rs775462909 CA8526298	125	F>L		No	ClinGen ExAC TOPMed gnomAD
CA8526297 rs765259627	126	N>S		No	ExAC TOPMed gnomAD ClinGen
CA398778483 rs1160384008	128	R>T		No	gnomAD ClinGen
rs1473817882 CA398778470	129	F>V		No	ClinGen gnomAD
rs1355712969 CA398778454	130	G>V		No	ClinGen TOPMed
CA8526294 rs771983120	131	Y>*		No	ClinGen ExAC gnomAD
rs200754841 CA8526296	131	Y>C		No	ClinGen ExAC gnomAD
CA290321049 rs772933053	132	R>C		No	ClinGen ExAC TOPMed gnomAD
rs772933053 CA8526293	132	R>G		No	ClinGen ExAC TOPMed gnomAD
rs774510625 CA8526292	132	R>H		No	ExAC TOPMed gnomAD ClinGen
rs186905613 CA8526290	135	T>A		No	ClinGen 1000Genomes ExAC gnomAD
rs780464546 CA8526289	136	P>A		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	136	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA398778377 rs1230076451	137	A>V		No	ClinGen gnomAD
rs372805713 CA8526288	139	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA398778342 rs1274233834	141	S>R		No	gnomAD ClinGen
rs201689032 CA8526287	142	T>M		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
CA8526285 rs569897835	144	V>I		No	1000Genomes ExAC TOPMed gnomAD ClinGen
TCGA novel	146	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8526283 rs376528529	146	G>R		No	ESP ExAC TOPMed gnomAD ClinGen
TCGA novel	148	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1296555776 CA398778250	149	T>N		No	TOPMed ClinGen
rs768546962 CA290321014	150	H>R		No	ClinGen Ensembl
rs1338659291 CA398778239	150	H>Y		No	TOPMed gnomAD ClinGen
CA8526281 rs530141761	152	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD

No associated diseases with A8MV24

No regional properties for A8MV24

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for A8MV24

Functions

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

No GO annotations of cellular component

Name	Definition
No GO annotations for cellular component

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

No GO annotations of biological process

Name	Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MAYLSECRLR	LEKGFILDGV	AVSTAARAYG	RSRPKLWSAI	PPYNAQQDYH	ARSYFQSHVV
70	80	90	100	110	120
PPLLRKTDQD	HGGTGRDGWI	VDYIHIFGQG	QRYLNRRNWA	GTGHSLQQVT	GHDHYNADLK
130	140	150
PIDGFNGRFG	YRRNTPALRQ	STSVFGEVTH	FPLF