A8LME6
Gene name |
Dshi_1749 |
Protein name |
Putative glutamate--cysteine ligase 2 |
Names |
Gamma-glutamylcysteine synthetase 2, GCS 2, Gamma-GCS 2 |
Species |
Dinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12) |
KEGG Pathway |
dsh:Dshi_1749 |
EC number |
6.3.2.2: Acid--amino-acid ligases (peptide synthases) |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A8LME6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A8LME6-F1 | Predicted | AlphaFoldDB |
No variants for A8LME6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A8LME6 | |||||
No associated diseases with A8LME6
No regional properties for A8LME6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for A8LME6 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 6.3.2.2 | Acid--amino-acid ligases (peptide synthases) |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| glutamate-cysteine ligase activity | Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H(+) + phosphate. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular modified amino acid biosynthetic process | The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSTPEFTLGI | EEEYLLVDRD | SLQLAEAPEA | LMAACRDKLE | GQVSPEFLQC | QIEIGTGVCA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EIAEARADLR | KLRSTVAAEA | ARFNLAPIAA | SCHPSADWAE | QHHTDKDRYN | DLEKDLGGVA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RRLLICGMHV | HVGLDDDDLR | IDLLPQFSYF | LPHLLALSSS | SPFWKGQDTG | LASYRLTVFD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NLPRTGLPPV | FNSWAEYQRN | IHVLIDLGLI | EDSSKIWWDL | RPSHNFPTLE | SRICDVCPRL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EDTLSLAAAT | QALMRMLWGL | KTHNMRWRAY | DRFLISENRW | RAQRYGARGS | LIDFGRGAVV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DSTELVEELI | ELIGADARAL | GGLAEVERLR | EIAADGSSAD | RQRAVRRAAL | EAGQSDAEAM |
| 370 | |||||
| NAVVRHLIEE | FHRDL |