A8LL46

PR
Gene name
argH
Protein name
Argininosuccinate lyase
Names
ASAL, Arginosuccinase
Species
Dinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12)
KEGG Pathway
dsh:Dshi_3062
EC number
4.3.2.1: Lyases acting on amides, amidines, etc
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

163-249 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A8LL46

Entry ID Method Resolution Chain Position Source
AF-A8LL46-F1 Predicted AlphaFoldDB

No variants for A8LL46

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A8LL46

No associated diseases with A8LL46

3 regional properties for A8LL46

Type Name Position InterPro Accession
conserved_site Fumarate lyase, conserved site 281 - 290 IPR020557
domain Fumarate lyase, N-terminal 12 - 306 IPR022761
domain Argininosuccinate lyase, C-terminal 369 - 438 IPR029419

Functions

Description
EC Number 4.3.2.1 Lyases acting on amides, amidines, etc
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

1 GO annotations of molecular function

Name Definition
argininosuccinate lyase activity Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine.

1 GO annotations of biological process

Name Definition
arginine biosynthetic process via ornithine The chemical reactions and pathways resulting in the formation of arginine (2-amino-5-guanidinopentanoic acid) via the intermediate compound ornithine.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSDTKSNAMW GGRFAAGPDA IMEAINASIG FDRRLARQDI DGSRAHAAML AQQGILSSKD
70 80 90 100 110 120
AEAIREGLLT VLSEIETGQF AFSAALEDIH MNVEARLKEL IGEPAGRLHT GRSRNDQVAT
130 140 150 160 170 180
DFKLWVRDQL DAADAGLLAL LRALLAQAEA GADWVMPGFT HLQTAQPVTW GHHMMAYVEM
190 200 210 220 230 240
FARDRGRMQD ARARMNECPL GAAALAGTSF PLDRDATAQA LGFDRPAANS LDAVSDRDFA
250 260 270 280 290 300
LEFLAAASIC AMHLSRMAEE LVIWSSAQFR FVTLSDRFST GSSIMPQKKN PDAAELIRAK
310 320 330 340 350 360
IGRIVGANVA LLTVMKGLPL AYSKDMQEDK EQVFDAADTL MLALAAMEGM VRDMTANRAS
370 380 390 400 410 420
LEDAAASGFS TATDLADWLV RELNLPFRDA HHVTGTLVAM AEAKGCDLPD LSLAEMQSVH
430 440 450 460
GAIRADVFEV LGVHNSVASR TSYGGTAPSQ VRAQVARWKE RLG