Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A8KAM8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A8KAM8-F1 | Predicted | AlphaFoldDB |
No variants for A8KAM8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A8KAM8 | |||||
No associated diseases with A8KAM8
16 regional properties for A8KAM8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 600 - 962 | IPR000719 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 601 - 956 | IPR001245 |
| conserved_site | Tyrosine-protein kinase, receptor class III, conserved site | 659 - 672 | IPR001824 |
| domain | Immunoglobulin subtype 2 | 45 - 107 | IPR003598-1 |
| domain | Immunoglobulin subtype 2 | 226 - 298 | IPR003598-2 |
| domain | Immunoglobulin subtype 2 | 331 - 403 | IPR003598-3 |
| domain | Immunoglobulin subtype | 39 - 121 | IPR003599-1 |
| domain | Immunoglobulin subtype | 220 - 311 | IPR003599-2 |
| domain | Immunoglobulin subtype | 325 - 416 | IPR003599-3 |
| domain | Immunoglobulin-like domain | 27 - 117 | IPR007110-1 |
| domain | Immunoglobulin-like domain | 214 - 307 | IPR007110-2 |
| active_site | Tyrosine-protein kinase, active site | 822 - 834 | IPR008266 |
| domain | Immunoglobulin I-set | 333 - 413 | IPR013098 |
| domain | Immunoglobulin | 40 - 110 | IPR013151 |
| binding_site | Protein kinase, ATP binding site | 606 - 634 | IPR017441 |
| domain | Tyrosine-protein kinase, catalytic domain | 600 - 958 | IPR020635 |
Functions
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasmic vesicle | A vesicle found in the cytoplasm of a cell. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| lysosomal lumen | The volume enclosed within the lysosomal membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| growth factor binding | Binding to a growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate. |
| platelet-derived growth factor beta-receptor activity | Combining with platelet-derived growth factor isoform PDGF-BB or PDGF-AB to initiate a change in cell activity. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| chemotaxis | The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). |
| positive regulation of cell migration | Any process that activates or increases the frequency, rate or extent of cell migration. |
| positive regulation of cell population proliferation | Any process that activates or increases the rate or extent of cell proliferation. |
| positive regulation of kinase activity | Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. |
| positive regulation of MAPK cascade | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade. |
| positive regulation of protein modification process | Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein. |
| protein autophosphorylation | The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). |
| vascular endothelial growth factor signaling pathway | The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding its receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRLPGAMPAL | ALKGELLLLS | LLLLLEPQIS | QGLVVTPPGP | ELVLNVSSTF | VLTCSGSAPV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VWERMSQEPP | QEMAKAQDGT | FSSVLTLTNL | TGLDTGEYFC | THNDSRGLET | DERKRLYIFV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PDPTVGFLPN | DAEELFIFLT | EITEITIPCR | VTDPQLVVTL | HEKKGDVALP | VPYDHQRGFS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GIFEDRSYIC | KTTIGDREVD | SDAYYVYRLQ | VSSINVSVNA | VQTVVRQGEN | ITLMCIVIGN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EVVNFEWTYP | RKESGRLVEP | VTDSLLDMPY | HIRSILHIPS | AELEDSGTYT | CNVTESVNDH |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QDEKAINITV | VESGYVRLLG | EVGTLQFAEL | HRSRTLQVVF | EAYPPPTVLW | FKDNRTLGDS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SAGEIALSTR | NVSETRYVSE | LTLVRVKVAE | AGHYTMRAFH | EDAEVQLSFQ | LQINVPVRVL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ELSESHPDSG | EQTVRCRGRG | MPQPNIIWSA | CRDLKRCPRE | LPPTLLGNSS | EEESQLETNV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| TYWEEEQEFE | VVSTLRLQHV | DRPLSVRCTL | RNAVGQDTQE | VIVVPHSLPF | KVVVISAILA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LVVLTIISLI | ILIMLWQKKP | RYEIRWKVIE | SVSSDGHEYI | YVDPMQLPYD | STWELPRDQL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| VLGRTLGSGA | FGQVVEATAH | GLSHSQATMK | VAVKMLKSTA | RSSEKQALMS | ELKIMSHLGP |
| 670 | 680 | 690 | 700 | 710 | 720 |
| HLNVVNLLGA | CTKGGPIYII | TEYCRYGDLV | DYLHRNKHTF | LQHHSDKRRP | PSAELYSNAL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| PVGLPLPSHV | SLTGESDGGY | MDMSKDESVD | YVPMLDMKGD | VKYADIESPN | YMAPYDNYVP |
| 790 | 800 | 810 | 820 | 830 | 840 |
| SAPERTCRAT | LINESPVLSY | MDLVGFSYQV | ANGMEFLASK | NCVHRDLAAR | NVLICEGKLV |
| 850 | 860 | 870 | 880 | 890 | 900 |
| KICDFGLARD | IMRDSNYISK | GSTFLPLKWM | APESIFNSLY | TTLSDVWSFG | ILLWEIFTLG |
| 910 | 920 | 930 | 940 | 950 | 960 |
| GTPYPELPMN | EQFYNAIKRG | YRMAQPAHAS | DEIYEIMQKC | WEEKFEIRPP | FSQLVLLLER |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| LLGEGYKKKY | QQVDEEFLRS | DHPAILRSQA | RLPGFHGLRS | PLDTSSVLYT | AVQPNEGDND |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| YIIPLPDPKP | EVADEGPLEG | SPSLASSTLN | EVNTSSTISC | DSPLEPQDEP | EPEPQLELQV |
| 1090 | 1100 | ||||
| EPEPELEQLP | DSGCPAPRAE | AEDSFL |