A8H1U8

PR
Gene name
gshA
Protein name
Glutamate--cysteine ligase
Names
Gamma-ECS, GCS, Gamma-glutamylcysteine synthetase
Species
Shewanella pealeana (strain ATCC 700345 / ANG-SQ1)
KEGG Pathway
spl:Spea_1208
EC number
6.3.2.2: Acid--amino-acid ligases (peptide synthases)
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-48 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A8H1U8

Entry ID Method Resolution Chain Position Source
AF-A8H1U8-F1 Predicted AlphaFoldDB

No variants for A8H1U8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A8H1U8

No associated diseases with A8H1U8

1 regional properties for A8H1U8

Type Name Position InterPro Accession
domain Glutamate--cysteine ligase 10 - 383 IPR007370

Functions

Description
EC Number 6.3.2.2 Acid--amino-acid ligases (peptide synthases)
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
glutamate-cysteine ligase activity Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H(+) + phosphate.

1 GO annotations of biological process

Name Definition
glutathione biosynthetic process The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKSFNELVGK LSDPASRQAL KSMQRGIERE ALRIEKSGHL ALDKHPKALG SALTHSRITT
70 80 90 100 110 120
DYSESLLEFI TPVFADIDEL VEDLTLTHAY SVRHLNGQRL WPVSMPCYLG DGADIPIADY
130 140 150 160 170 180
GSSNSGQMKS LYRKGLTYRY GAQMQIISGV HFNFSVSDKL WHRLYELSDK SLSLDDFISD
190 200 210 220 230 240
SYFGLIRNYR RLVWVLPYLF GASPALCSTF IQDPKTSNFP FEVIGDGTLF MPYATSLRMS
250 260 270 280 290 300
DLGYTNQEQD NLNISYNSLT DYLTGMQAAI NMPSANFAKI GVKVDGEYRQ LNDNILQIEN
310 320 330 340 350 360
EFYSPIRAKR VAKGSEKPSE SLARAGVEYI EVRALDVNPY SAVGIEKSQI RFLDLFLLNC
370 380 390 400 410 420
LLQPSAPSDA TEEAEIAENL QAVVLEGRKP GLLLKRSGQE LSLTHWLESL FGNLKQIAQL
430 440 450 460 470 480
LDDEGQDDYQ VALAKWHKAV ENPNETLSGK IMAGLKDEQV DHSEWVMELA EQYHQQLKAY
490 500 510 520
PLTENVDKRY QQDAVESLEK QAYLESQPSV SFDQFLVDYF KV