A8H1T4

PR
Gene name
mutS
Protein name
DNA mismatch repair protein MutS
Names
Species
Shewanella pealeana (strain ATCC 700345 / ANG-SQ1)
KEGG Pathway
spl:Spea_1194
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

768-859 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A8H1T4

Entry ID Method Resolution Chain Position Source
AF-A8H1T4-F1 Predicted AlphaFoldDB

No variants for A8H1T4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A8H1T4

No associated diseases with A8H1T4

5 regional properties for A8H1T4

Type Name Position InterPro Accession
domain DNA mismatch repair protein MutS, C-terminal 611 - 801 IPR000432
domain DNA mismatch repair protein MutS-like, N-terminal 13 - 124 IPR007695
domain DNA mismatch repair protein MutS, core 274 - 595 IPR007696
domain DNA mismatch repair protein MutS, connector domain 133 - 257 IPR007860
domain DNA mismatch repair protein MutS, clamp 432 - 521 IPR007861

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP-dependent DNA damage sensor activity A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis.
damaged DNA binding Binding to damaged DNA.
mismatched DNA binding Binding to a double-stranded DNA region containing one or more mismatches.

1 GO annotations of biological process

Name Definition
mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTAIDPQSLE KHTPMMRQYL TLKAQHPDML LFYRMGDFYE LFYEDAKKAS ELLGISLTAR
70 80 90 100 110 120
GKSGGDPIPM AGLPYHAVEG YLAKLVQLRV SVAICEQVGD PATSKGPVER KVVRIVTPGT
130 140 150 160 170 180
LTDEALLQER QDNLLAALYQ GKTGYGYATL DVASGRFVVT ELANTEALEA ELQRTNPAEL
190 200 210 220 230 240
LYSEDFSQMS LIAGMNGTRR RPEWEFDYDT CQRMLLNQFG TKDLKGFGIE DARLSLQAAG
250 260 270 280 290 300
CLMQYVKDTQ RTALPHINSI VRFNQSDSIV LDAATRRNLE LTVNLQGGRE NTLASVLDNT
310 320 330 340 350 360
VTPMGSRMLQ RWIHQPLRDH DIIRARQASI AELMMTGDFE TLSEDLKALG DVERITARIA
370 380 390 400 410 420
LRNARPRDFA RLRQALTLLP QLQQTLSAAS APHLKYLSQV IGVFPEEVDL LSRAVVDNPP
430 440 450 460 470 480
MLIRDGGVIR EGYNEELDQW RKLSEGATDY LHELEAREKE QTGISTLKVG YNRVHGYYIE
490 500 510 520 530 540
VSRRESDLVP LSYQRRQTLK NTERYIIPEL KEHEEKVLSS QGRALALEKQ LWEQLFDLIL
550 560 570 580 590 600
PKLHELQDFA QASAELDVLC NFAERAESLN YHCPELSSIS GIHIEAGRHP VVEQVSQSPF
610 620 630 640 650 660
IANPVTLNAQ RKMLIVTGPN MGGKSTYMRQ VALITLMAHI GCYVPAEQAV IGPVDRIFTR
670 680 690 700 710 720
IGASDDLASG RSTFMVEMTE TANILHNATP NSLVLMDEIG RGTSTYDGLS LAWSAAEYLA
730 740 750 760 770 780
KQLQAMTLFA THYFELTQLP EQLSNVENVH LDAVEHGDSI VFMHAVQEGA ASRSYGLQVA
790 800 810 820 830 840
ALAGVPNCVI SAAKHKLHQL ESRDHDVQQN TEQQGTQQNM SFVPSAPSPA VEALQKLNPD
850
ELTPRQALDY LYNLKKLAL