A8GFA0

PR
Gene name
clsA
Protein name
Cardiolipin synthase A
Names
CL synthase
Species
Serratia proteamaculans (strain 568)
KEGG Pathway
spe:Spro_2689
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

40-131 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A8GFA0

Entry ID Method Resolution Chain Position Source
AF-A8GFA0-F1 Predicted AlphaFoldDB

No variants for A8GFA0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A8GFA0

No associated diseases with A8GFA0

5 regional properties for A8GFA0

Type Name Position InterPro Accession
domain Phospholipase D/Transphosphatidylase 229 - 256 IPR001736-1
domain Phospholipase D/Transphosphatidylase 407 - 434 IPR001736-2
domain Phospholipase D-like domain 146 - 274 IPR025202-1
domain Phospholipase D-like domain 335 - 460 IPR025202-2
domain Cardiolipin synthase N-terminal 25 - 68 IPR027379

Functions

Description
EC Number
Subcellular Localization
  • Cell inner membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
cardiolipin synthase activity Catalysis of the reaction: phosphatidylglycerol + phosphatidylglycerol = diphosphatidylglycerol (cardiolipin) + glycerol.

1 GO annotations of biological process

Name Definition
cardiolipin biosynthetic process The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTTFYTVISW LMVFGYWLLI AGVTLRILMK RRAVPSAMAW LLVIYILPLF GIVAYLSFGE
70 80 90 100 110 120
LHLGKRRAER AKAMWPSTAR WLSELKESQR IFATDYSEVA RPLFQLCDRR QGIDGVKGNQ
130 140 150 160 170 180
LQLLTTTDAT LKALIRDIEL ARHNIEMVFY IWQPGGLVDQ VAESLMAAAR RGVHCRLMLD
190 200 210 220 230 240
SAGSLQFFRS PYPGMMRNAG IEVVEALKVN LFRVFLRRMD LRQHRKVVLI DNYIAYTGSM
250 260 270 280 290 300
NMVDPRYFKQ DAGVGQWIDL MARMEGPVAS TMGIVYACDW EIETGKRILP PPPDVNIMPF
310 320 330 340 350 360
EQESGHTIQV IASGPGFPEE MIHQALLTAV YSAREQLIMT TPYFVPSDDL LHAICTAALR
370 380 390 400 410 420
GVEVSIIVPR DNDSTMVRWA SRSFFSELLE AGVRIYQFED GLLHTKSVLV DGQLSLVGTV
430 440 450 460 470 480
NLDMRSLWLN FEITLVIDDD GFGSDLACVQ DDYIARSQLL NAAEWQKRPF WHRIVERLFY
FFSPLL