A8G2X2

PR
Gene name
metK
Protein name
S-adenosylmethionine synthase
Names
AdoMet synthase, MAT, Methionine adenosyltransferase
Species
Prochlorococcus marinus (strain MIT 9215)
KEGG Pathway
pmh:P9215_03361
EC number
2.5.1.6: Transferring alkyl or aryl groups, other than methyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-41 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A8G2X2

Entry ID Method Resolution Chain Position Source
AF-A8G2X2-F1 Predicted AlphaFoldDB

No variants for A8G2X2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A8G2X2

No associated diseases with A8G2X2

2 regional properties for A8G2X2

Type Name Position InterPro Accession
domain Homogentisate 1,2-dioxygenase, C-terminal domain 295 - 446 IPR046451
domain Homogentisate 1,2-dioxygenase, N-terminal domain 20 - 293 IPR046452

Functions

Description
EC Number 2.5.1.6 Transferring alkyl or aryl groups, other than methyl groups
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
magnesium ion binding Binding to a magnesium (Mg) ion.
methionine adenosyltransferase activity Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine.

2 GO annotations of biological process

Name Definition
one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states.
S-adenosylmethionine biosynthetic process The chemical reactions and pathways resulting in the formation of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSDFIFTSES VTEGHPDKIC DQISDAVLDA LLTEDPESRV ACETVVNTGL CLLTGEITSK
70 80 90 100 110 120
AKVDYIKLVR NVIKEIGYEG YKAGGFDANS CAVLVALDEQ SPDISQGVNE ADDVNDDLED
130 140 150 160 170 180
NTGAGDQGIM FGYACDETPE LMPLPISLAH RLAIQLAKVR HENLLNYLLP DGKTQVSIDY
190 200 210 220 230 240
EKGLPVSINT ILISTQHNPE IDGLTNEEEI RQRIKEDLWK HVVIPATEDL EIKPNIIKTR
250 260 270 280 290 300
FLVNPTGKFV VGGPQGDAGL TGRKIIVDTY GGYARHGGGA FSGKDPTKVD RSAAYAARYV
310 320 330 340 350 360
AKSIVKAKLA KKAEVQLSYA IGVAKPISIL VDTFDTGVIS QANLTELIKK YFDLRPAAII
370 380 390 400 410
KEFDLRNLPQ KMGGKFFRKT ASYGHFGRRD LDLPWEKVEE KAAQLAEASK VFL