A8FTT1

PR
Gene name
mnmC
Protein name
tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC
Names
tRNA mnm(5)s(2)U biosynthesis bifunctional protein
Species
Shewanella sediminis (strain HAW-EB3)
KEGG Pathway
sse:Ssed_1643
EC number
2.1.1.61: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-66 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A8FTT1

Entry ID Method Resolution Chain Position Source
AF-A8FTT1-F1 Predicted AlphaFoldDB

No variants for A8FTT1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A8FTT1

No associated diseases with A8FTT1

5 regional properties for A8FTT1

Type Name Position InterPro Accession
conserved_site MnmG-related, conserved site 273 - 287 IPR020595-1
conserved_site MnmG-related, conserved site 368 - 391 IPR020595-2
domain tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, C-terminal 402 - 616 IPR026904
domain MnmG, N-terminal domain 8 - 398 IPR040131
domain tRNA uridine 5-carboxymethylaminomethyl modification enzyme, C-terminal subdomain 546 - 617 IPR047001

Functions

Description
EC Number 2.1.1.61 Methyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
flavin adenine dinucleotide binding Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
oxidoreductase activity, acting on the CH-NH group of donors Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing 5-aminomethyl-2-thiouridine = S-adenosyl-L-homocysteine + tRNA containing 5-methylaminomethyl-2-thiouridylate.

1 GO annotations of biological process

Name Definition
tRNA wobble base modification The process in which the nucleotide at position 34 in the anticodon of a tRNA is post-transcriptionally modified.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPNMRHRVNS LTEEHEENMQ MSKLTGHLSS ISTLFPVKND ASQTLTLGQL GLGCPCQLVS
70 80 90 100 110 120
LWHYLRKNSP SRAVNIKIFE SQFDALADFN LKLASLTSPD PRLPRDDEQS TMVEALLRAD
130 140 150 160 170 180
IVAIEGCQRL IFDDGRVILD IYLGDTLSQL KCILPTSVKG DMTDNSALIA HWNITEKVKA
190 200 210 220 230 240
GSLDQAMLWQ IAKLSRDNAA LSFTDPESKE TRQMMALARS VGLRTLETTV SETTVPETQQ
250 260 270 280 290 300
QTENKNLDTA SDAIPLQERR ALRHAQSDKF QYCPVSAANE GDEDCDGEIA IIGGGVASTH
310 320 330 340 350 360
LALSLAQRNK KVRIFCSDAN FAQQASGNKQ GAVYPLLTPD NGHLSHYFQQ GYLFTRRRLQ
370 380 390 400 410 420
ALVDDKFAVS YDFCGVLQTG FDDRSSARLD KIINGQSWNE KMAYPIDAAS ATQIAGIDID
430 440 450 460 470 480
KAGIYYPLGG WICPHEFTRA AFDKAARLSD VSVEFNADIT RIEQREGLWY LYKSVNVQHS
490 500 510 520 530 540
CTDSHTPDDS EELEIGPFAN LVLANGQGLT QFKQSEKLPA TGFRGQVSHI PSRNALTKLS
550 560 570 580 590 600
TVLCSHGYLT PGNNNFHCTG ASYVKNPTNL DYCATEQVEN LHKIRHSYVD KPWTEDVDIT
610 620 630 640 650 660
GHSARVGVRM VTRDHAPMMG CAPDTDSMLA QYEQHQHTKE SIKFWKETPA PTHKGLFILG
670 680 690 700 710
GLGSRGLTSG PLAAEALAAQ LCGEVIPLSM PMLEMLNPNR FWMRKLIKGK AL