A8FGA6

PR
Gene name
tyrS
Protein name
Tyrosine--tRNA ligase
Names
Tyrosyl-tRNA synthetase, TyrRS
Species
Bacillus pumilus (strain SAFR-032)
KEGG Pathway
bpu:BPUM_2615
EC number
6.1.1.1: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

312-409 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A8FGA6

Entry ID Method Resolution Chain Position Source
AF-A8FGA6-F1 Predicted AlphaFoldDB

No variants for A8FGA6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A8FGA6

No associated diseases with A8FGA6

2 regional properties for A8FGA6

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 40 - 50 IPR001412
domain RNA-binding S4 domain 356 - 417 IPR002942

Functions

Description
EC Number 6.1.1.1 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
RNA binding Binding to an RNA molecule or a portion thereof.
tyrosine-tRNA ligase activity Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H(+).

1 GO annotations of biological process

Name Definition
tyrosyl-tRNA aminoacylation The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. The tyrosyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tyrosine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSQLMEELSF RGLIQQQTDE EGLTKLLAEE KIKLYSGFDP TADSLHIGHL LPILTLRRFQ
70 80 90 100 110 120
EAGHHPIALV GGATGLIGDP SFKKAERSLN PAEIVEHWSD KIKGQLSQFL DFEAGENPAV
130 140 150 160 170 180
IVNNYDWISQ MNVITFLRDI GKNFGVNFML AKDIVSSRIE TGISYTEFSY VILQSLDFLN
190 200 210 220 230 240
LYRNENCKLQ IGGSDQWGNI TSGLELIRKS EAEGAKAFGL TMPLVTKADG TKFGKTEGGA
250 260 270 280 290 300
IWLDKEKTSP YEFYQFWINT DDRDVVKYLK YFTFLSKEEI ASYEEKVQTA PEKREAQRRL
310 320 330 340 350 360
AEEVTTLVHG RESLEQAVNI SNALFKGEIK SLSAEEVKVG FKDVPSMEKS STEELTLVDL
370 380 390 400 410 420
LVESKLSPSK RQAREDITNG AVSINGERQT DKDYVLSAED RIENQFTVLR RGKKKYFLVT
YK