A8F976

PR
Gene name
rpoB
Protein name
DNA-directed RNA polymerase subunit beta
Names
RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta
Species
Bacillus pumilus (strain SAFR-032)
KEGG Pathway
bpu:BPUM_0093
EC number
2.7.7.6: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

451-528 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A8F976

Entry ID Method Resolution Chain Position Source
AF-A8F976-F1 Predicted AlphaFoldDB

No variants for A8F976

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A8F976

No associated diseases with A8F976

3 regional properties for A8F976

Type Name Position InterPro Accession
domain RNA polymerase, alpha subunit, C-terminal 253 - 310 IPR011260
domain DNA-directed RNA polymerase, insert domain 69 - 158 IPR011262
domain DNA-directed RNA polymerase, RpoA/D/Rpb3-type 28 - 235 IPR011263

Functions

Description
EC Number 2.7.7.6 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
DNA-directed RNA polymerase complex A protein complex that possesses DNA-directed RNA polymerase activity.

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
ribonucleoside binding Binding to a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose.

1 GO annotations of biological process

Name Definition
DNA-templated transcription The synthesis of an RNA transcript from a DNA template.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNQLTGQLVQ YGRHRQRRSY ARISEVLELP NLIEIQTSSY QWFLDEGLRE MFQDISPIED
70 80 90 100 110 120
FTGNLSLEFI DYSLGDPKYP VAESKERDVT YSAPLRVKVR LINKETGEVK DQDVFMGDFP
130 140 150 160 170 180
IMTDTGTFII NGAERVIVSQ LVRSPSVYFS GKVDKNGKKG FTATVIPNRG AWLEYETDAK
190 200 210 220 230 240
DVVYVRIDRT RKLPVTVLLR ALGFSSDQEI LDLIGENEYL RNTLEKDNTE NADKALLEIY
250 260 270 280 290 300
ERLRPGEPPT VENAKSLLDS RFFDPKRYDL ANVGRYKINK KLHIKNRLFN QKLAETLVDP
310 320 330 340 350 360
ETGEILAEKG QILDRRVLDK VLPYLENGIG FRKLYPNGGV VEDEVELQSI KIYAPSDQEG
370 380 390 400 410 420
EQVINVIGNA YVEEAVKNIT PSDIIASISY FFNLLHGVGD TDDIDHLGNR RLRSVGELLQ
430 440 450 460 470 480
NQFRIGLSRM ERVVRERMSI QDTNTITPQQ LINIRPVIAS IKEFFGSSQL SQFMDQTNPL
490 500 510 520 530 540
AELTHKRRLS ALGPGGLTRE RAGMEVRDVH YSHYGRMCPI ETPEGPNIGL INSLSSFAKV
550 560 570 580 590 600
NRFGFIETPY RRVDPETGKV TPRIDYLTAD EEDNYVVAQA NALLADDGSF IDDNIIARFR
610 620 630 640 650 660
GENTVVPRNR VDYMDVSPKQ VVSAATACIP FLENDDSNRA LMGANMQRQA VPLMQPESPI
670 680 690 700 710 720
VGTGMEYVSG KDSGAAVICR YPGVVERVEA KNIWVRRYED VDGQQVKGNL DKYSLLKFVR
730 740 750 760 770 780
SNQGTCYNQR PIVSVGDEVV KGEILADGPS MEKGELALGR NVMVGFMTWD GYNYEDAIIM
790 800 810 820 830 840
SERLVKDDVY TSIHIEEYES EARDTKLGPE EITRDIPNVG EDALRNLDER GIIRIGAEVK
850 860 870 880 890 900
DGDLLVGKVT PKGVTELTAE ERLLHAIFGE KAREVRDTSL RVPHGGGGII HDVKVFNRED
910 920 930 940 950 960
GDELPPGVNQ LVRVYIVQKR KISEGDKMAG RHGNKGVISK ILPEEDMPYL PDGTPIDIML
970 980 990 1000 1010 1020
NPLGVPSRMN IGQVLELHMG MAARYLGIHI ASPVFDGARE EDVWETLEEA GMSRDAKTVL
1030 1040 1050 1060 1070 1080
YDGRTGEPFD NRVSVGIMYM IKLAHMVDDK LHARSTGPYS LVTQQPLGGK AQFGGQRFGE
1090 1100 1110 1120 1130 1140
MEVWALEAYG AAYTLQEILT VKSDDVVGRV KTYEAIVKGD NVPEPGVPES FKVLIKELQS
1150 1160 1170 1180 1190
LGMDVKILSG DEEEIEMRDL EDDEETKKAD GLALSNDEDA ADLAPVDLER DAVTKE