A8F753

PR
Gene name
mutS
Protein name
DNA mismatch repair protein MutS
Names
Species
Pseudothermotoga lettingae (strain ATCC BAA-301 / DSM 14385 / NBRC 107922 / TMO) (Thermotoga lettingae)
KEGG Pathway
tle:Tlet_1431
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

750-811 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A8F753

Entry ID Method Resolution Chain Position Source
AF-A8F753-F1 Predicted AlphaFoldDB

No variants for A8F753

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A8F753

No associated diseases with A8F753

5 regional properties for A8F753

Type Name Position InterPro Accession
domain DNA mismatch repair protein MutS, C-terminal 588 - 775 IPR000432
domain DNA mismatch repair protein MutS-like, N-terminal 4 - 110 IPR007695
domain DNA mismatch repair protein MutS, core 257 - 573 IPR007696
domain DNA mismatch repair protein MutS, connector domain 119 - 235 IPR007860
domain DNA mismatch repair protein MutS, clamp 410 - 500 IPR007861

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP-dependent DNA damage sensor activity A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis.
damaged DNA binding Binding to damaged DNA.
mismatched DNA binding Binding to a double-stranded DNA region containing one or more mismatches.

1 GO annotations of biological process

Name Definition
mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKLTPMMQQY MDIKSKYKDA ILLFRLGDFY EAFFEDAEIV SKTLDLVLTH RQDAPMAGVP
70 80 90 100 110 120
YHALNTYLKK LVQFGYKVAI CDQVEDPSTA KGLVKREVTR IVTPGTVLED DLLDQNSNNY
130 140 150 160 170 180
LVAICRKSEY SVAGVDISTG ESFVVSFKDF QSMIDFLGSV KVSQVLCEPD LRQDLEKNLA
190 200 210 220 230 240
DIMIESLADW HLDDALLEKD IAEVFKVSDI DHLELGSNLK VFGALVRYLR YTLMSPCTLV
250 260 270 280 290 300
KPPRIIRDQM YVFLDPATIE HLSLVGGEKG KNLFDVLNHT KTSMGSRLLK NWILQPLRDL
310 320 330 340 350 360
YEINKRLDKV QAFVEDSILL NEIREYLQAV RDIQRIANRI NYGKASVKDL VALRSTLQVC
370 380 390 400 410 420
PYIKEVLLTN EAFPEAAMVD CLHDICEILN DAIKEEPSSV IGEGKVIKEG YDEQLDQLRE
430 440 450 460 470 480
LVYHSQEFLN NFEQRERDRT GIPNLRVGYN SVFGYYIEIT KSHLSKIPPN YVRKQTLVNA
490 500 510 520 530 540
ERFITDELKE FEQKMLTAKE NLERREKEIY DEICASLSSK VGLIIELAEF LAQIDVLSTL
550 560 570 580 590 600
AYVAIRYGYT KPSFSNDGKL LLRNSRHPVV ERLVDTFVPN DLEMDRTKNF IILTGPNMSG
610 620 630 640 650 660
KSTFIRQVAL VSIMAQMGSF VPADEAILPV FDRIFAKMGI RDDIASGKST FLIEMNEVAK
670 680 690 700 710 720
IVYQATENSL ILLDEVGRGT STFDGISIAW AVSEYLQNQI SCKCIFATHF TELTELAKMY
730 740 750 760 770 780
DGIVNKTVQV IEEKNQVIFL HRVVDGIADR SYGIEVAGIA GLPGEIIQRA REVLDVIANK
790 800 810
SELEDKLRVI SSEKLKKLKK KKVHPNQAQL W