A8F346
Gene name |
dnaA |
Protein name |
Chromosomal replication initiator protein DnaA |
Names |
|
Species |
Pseudothermotoga lettingae (strain ATCC BAA-301 / DSM 14385 / NBRC 107922 / TMO) (Thermotoga lettingae) |
KEGG Pathway |
tle:Tlet_0001 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A8F346
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A8F346-F1 | Predicted | AlphaFoldDB |
No variants for A8F346
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A8F346 | |||||
No associated diseases with A8F346
5 regional properties for A8F346
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | AAA+ ATPase domain | 178 - 306 | IPR003593 |
| domain | Chromosomal replication initiator, DnaA C-terminal | 395 - 485 | IPR013159 |
| domain | Chromosomal replication initiator protein DnaA | 146 - 367 | IPR013317 |
| conserved_site | Chromosomal replication control, initiator DnaA, conserved site | 445 - 464 | IPR018312 |
| domain | DnaA N-terminal domain | 27 - 87 | IPR024633 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| DNA replication origin binding | Binding to a DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA replication initiation | The process in which DNA-dependent DNA replication is started; this begins with the ATP dependent loading of an initiator complex onto the DNA, this is followed by DNA melting and helicase activity. In bacteria, the gene products that enable the helicase activity are loaded after the initial melting and in archaea and eukaryotes, the gene products that enable the helicase activity are inactive when they are loaded and subsequently activate. |
| regulation of DNA replication | Any process that modulates the frequency, rate or extent of DNA replication. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKSEIIESLK | SKLNRRVWES | WFGTFDVKEI | GPDYVVFQVG | NLFIREWLEK | KYGSLISKTL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RELFGKPMDF | RIEHASAKTE | EKLDSNEDEP | LVKKRPLILT | PLNPILTFEN | FVVGPNNMFA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YSTCLEVAKN | PGKYNPLFLH | GGVGLGKTHL | LQAIGHYLFK | HEPDMRVIYL | TSERFLNELV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DSIKKNRVQE | FRDKFRNKID | VLLLDDVQFL | IGKTGIQTEL | FHTFNELYNE | GKQIVVCSDR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DPQQLEKFQD | RLVSRFQMGV | VTKIEKPDEE | TCFKIAQKMA | QLENAELQED | ILKLISKNFS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DNLRRLRGAL | VKLIMYQQIS | GEKVDLQKAF | ELLAIQNSYH | NKSLPEEKLM | NSICEIFGVS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QEEILSKSRK | KEVALARQIG | MYVARNYMGF | SLRKVADMFK | RSHPTVSHTI | QKLEELTNSG |
| 430 | 440 | ||||
| NMVIKSQIDR | LARCVTGQIL | DQSV |