A8F323

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Rickettsia massiliae (strain Mtu5)
KEGG Pathway
rms:RMA_1379
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

394-465 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A8F323

Entry ID Method Resolution Chain Position Source
AF-A8F323-F1 Predicted AlphaFoldDB

No variants for A8F323

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A8F323

No associated diseases with A8F323

4 regional properties for A8F323

Type Name Position InterPro Accession
domain DHHA1 domain 736 - 871 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 656 - 699 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 8 - 557 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 4 - 712 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTKFTTEEVR SKFITYFKAN NHTHVPTSSL IPHNDPSLMF VNSGMVQFKN VFTGQEKRPY
70 80 90 100 110 120
NKAVTSQKSL RAGGKHNDLE NVGYTARHHT FFEMLGNFSF GDYFKEQAIY YAWNLLTKEF
130 140 150 160 170 180
ELPKDKLYAT IYHTDDEAAS YWKKIAGFGD DRIIKIKTND NFWSMGDTGP CGPCSEIFYD
190 200 210 220 230 240
HGEQIYGGLP GTKDEDGDRF IEIWNMVFMQ YEQIDKDTSI ELSQKSIDTG MGLERMTAVL
250 260 270 280 290 300
QHVNNNYNID LFQEIINFTE NIVKVKVEGE AKFSYRVIAD HLRASSFLIA DGVIPSNEGR
310 320 330 340 350 360
GYVLRRIMRR SMRHAHMLGA KEPLMYKLLP KLVDLMGNVY PELKRAERFI SSILEQEEIR
370 380 390 400 410 420
FKATLERGLK LLTEETEMLT KGNELSGEVA FKLYDTYGFP LDLTEDILKT RDISVDHKGF
430 440 450 460 470 480
EEQMLMQKER ARKSWLGSGE SKTDQLWFDI KEQHGSTEFL GYTLNEAKCK IIALIKNNNL
490 500 510 520 530 540
VNDIKEIDTQ FLLISNQTPF YGESGGQIGD IGTIFAKDSE VEVIDTLKYL GSIIVHKCIL
550 560 570 580 590 600
KKGQINVGEN ANFSIDIRYR QNLRIHHSAT HILHAVLHEV LGKHVTQKGS LVAPTYLRFD
610 620 630 640 650 660
ISHSKAVTNE EITLIEDKVN EIIRDNHEVN TTFMATEDAV KQGAMALFGE KYDSEVRVVK
670 680 690 700 710 720
MGETSLELCA GTHVRRTGDI GCFKITSESA IAAGVRRIEA VCGEFVIKLM REKDSLLKSI
730 740 750 760 770 780
ESSLKTNKNE LITKVNNILE RNKEVEKELE KTHLASLDLS IEQIEKQAAQ ITGIKLLYKK
790 800 810 820 830 840
VGNIDNKILR QAAENLTKKV EDLIMVYIAE GIGKLSITVA VSKAITDKYN ADIIAKKLSL
850 860 870
FLGGSGGGGQ ASLAQAGGND IGKLTNIHKK LYSLLTVS