A8F0A4

PR
Gene name
mutL
Protein name
DNA mismatch repair protein MutL
Names
Species
Rickettsia canadensis (strain McKiel)
KEGG Pathway
rcm:A1E_05630
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

310-435 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A8F0A4

Entry ID Method Resolution Chain Position Source
AF-A8F0A4-F1 Predicted AlphaFoldDB

No variants for A8F0A4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A8F0A4

No associated diseases with A8F0A4

3 regional properties for A8F0A4

Type Name Position InterPro Accession
domain DNA mismatch repair protein, S5 domain 2-like 212 - 330 IPR013507
conserved_site DNA mismatch repair, conserved site 92 - 98 IPR014762
domain MutL, C-terminal, dimerisation 421 - 568 IPR014790

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
mismatch repair complex Any complex formed of proteins that act in mismatch repair.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
ATP-dependent DNA damage sensor activity A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis.
mismatched DNA binding Binding to a double-stranded DNA region containing one or more mismatches.

1 GO annotations of biological process

Name Definition
mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTIKFLSEST INRIAAGEVI ERPASVVKEL VENAVDASST KINIILERAG KNLIIISDDG
70 80 90 100 110 120
IGMTDKELEI AVERHTTSKL DESDFLKIHT FGFRGEALPS IAAISKMLIT SKKRGTDKAF
130 140 150 160 170 180
QIKLIGGNEK QITISVHNEG TKIEIRDLFF ATPARLKFLR ADKTELAVTV DIVKKIALAH
190 200 210 220 230 240
PEISFSLTND SKNLLKLKGQ NKDAETNLKQ RIIDVIGDDF IKNAAYIDFK ILDFSICGYT
250 260 270 280 290 300
SIPTYNRASS EDQFLFINNR PVKDKLLQVA LRVAYQDYLA RDRYPLCAIF LQIDPQFVDV
310 320 330 340 350 360
NVHPAKAEVR FHDPNYVRNL LIEAIKNALA NKSHVTSTTI ASDTLKLFKN PLINKQPTIN
370 380 390 400 410 420
KEVNVNSKSV DYRSYSSANT PKILQNHICQ KLIDTLPHAK VEQEVENRIE HKQQIHKQYK
430 440 450 460 470 480
LGAAKAQLHT TYIISQTEDS IVITDQHAAH ERLGYEKIKS YIKMDELIKQ RLLIPEIVEL
490 500 510 520 530 540
PNEKRADCLY DHREKLSKLG LTLEKFGEKS IIVTEIPNIL GDVNVQKLIQ DLADHLSDFS
550 560 570 580 590 600
ENVALMELIE HVTETYACHY SIRAGRKLSA DEMNALLRQM ENTPFSGQCN HGRPTYIELK
LKDIERLFGR