A8EZJ2

PR
Gene name
rpoA
Protein name
DNA-directed RNA polymerase subunit alpha
Names
RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha
Species
Rickettsia canadensis (strain McKiel)
KEGG Pathway
rcm:A1E_04250
EC number
2.7.7.6: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

209-280 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A8EZJ2

Entry ID Method Resolution Chain Position Source
AF-A8EZJ2-F1 Predicted AlphaFoldDB

No variants for A8EZJ2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A8EZJ2

No associated diseases with A8EZJ2

7 regional properties for A8EZJ2

Type Name Position InterPro Accession
domain DNA-directed RNA polymerase, subunit 2, hybrid-binding domain 576 - 976 IPR007120
conserved_site RNA polymerase, beta subunit, conserved site 814 - 826 IPR007121
domain RNA polymerase Rpb2, domain 7 978 - 1050 IPR007641
domain RNA polymerase Rpb2, domain 2 127 - 310 IPR007642
domain RNA polymerase, beta subunit, protrusion 18 - 354 IPR007644
domain RNA polymerase Rpb2, domain 3 369 - 437 IPR007645
domain DNA-directed RNA polymerase, beta subunit, external 1 domain 449 - 514 IPR019462

Functions

Description
EC Number 2.7.7.6 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
DNA-directed RNA polymerase complex A protein complex that possesses DNA-directed RNA polymerase activity.

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
protein dimerization activity The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.

1 GO annotations of biological process

Name Definition
DNA-templated transcription The synthesis of an RNA transcript from a DNA template.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLSLSKNWNA LIKPNKVAYE NVSETNNKAK IVVEPLERGF GLTLGNAMRR VLLSSLQGAA
70 80 90 100 110 120
ITSIKIPAIE HEFSAIPGVK EDVSEMILNI KGIEVKMYVA EKRIIKLKAI GPCVVTAGMI
130 140 150 160 170 180
ETGHDVEILN PDHVICNLAK NKQLEMELTC KVGKGYVLST NSYADNLPIG EIAIDALFNP
190 200 210 220 230 240
VKSVTYKVEN TRVGQVTDYD KLIMFVETNG DLLPEMAVGL AARILQEQLQ LFISFEEQEE
250 260 270 280 290 300
DKQVKTDALP FSPYLLKRVD ELELSVRSAN CLKNDNIIYI GDLVKRTEAD MLRTPNFGRK
310 320 330
SLNEIKEILA KLNLRFGMDV PDWPPENIQE LSKRYEDSDN