A8EWI6

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Aliarcobacter butzleri (strain RM4018) (Arcobacter butzleri)
KEGG Pathway
abu:Abu_2092
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

389-461 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A8EWI6

Entry ID Method Resolution Chain Position Source
AF-A8EWI6-F1 Predicted AlphaFoldDB

No variants for A8EWI6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A8EWI6

No associated diseases with A8EWI6

4 regional properties for A8EWI6

Type Name Position InterPro Accession
domain DHHA1 domain 721 - 844 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 643 - 686 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 2 - 544 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 1 - 699 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDIRKEYLEF FRSKGHEVIS SMPLVPDDPT LMFTNAGMVQ FKDIFTGAVP TPKNKRATSC
70 80 90 100 110 120
QLCVRAGGKH NDLENVGYTA RHHTLFEMLG NFSFGDYFKE DAIAYAWEFV TVNLALPIDK
130 140 150 160 170 180
LWVTVHNNDD EAFDIWSKYI NPSRIMRFGD KDNFWSMGDT GACGPCSEIF YDQGEENFNG
190 200 210 220 230 240
EEDYMGGDGD RFLEIWNLVF MQYERTADGK LNPLPKPSID TGMGLERVIA IKEGVFNNFD
250 260 270 280 290 300
SSNFKPIIKK IEEISSKNAT SENIGSYRVI ADHLRACSFM LSQGILFGNE GRPYVLRRIL
310 320 330 340 350 360
RRAVRHGYLI GFRKPFMAKL LDTLIEIMGG HYTELVENKN FIEEQLTLEE DRFFKTIDLG
370 380 390 400 410 420
MSLFNEELEK TKDIFSGVTA FKLYDTYGFP LDLTEDMLRD RGLKVDLAKF DELMNNQKAM
430 440 450 460 470 480
AKAAWKGSGD TSNEGDFKQL LEKFGSNEFV GYNNTTYKSK IIALLDEHFK EVKILEKDST
490 500 510 520 530 540
GWVMLDKTPF YATSGGQNGD IGALEDNKHI AIVEETTKFH GLNLSKVKVV NSSLKQGESV
550 560 570 580 590 600
DAIVVNRNEV AKHHSATHLL QSALKIVLGD TVSQAGSLND ASRLRFDFTY PKAMTKEQID
610 620 630 640 650 660
EVEDLVNSMI ARGISGNVEE LPIEQAKKKG AIAMFGEKYG DVVRVVSFED VSVEFCGGTH
670 680 690 700 710 720
VRNTADIGSF YIVKESGVSA GVRRIEAVCG TAAIKYTKDI ISKMNEIQAE VKNSDVILGI
730 740 750 760 770 780
KKLKEQIKDL KKEIETSQSK TSSPIEETII NDTKVIVSVV ENGDLKKIVD DTKNANEKVA
790 800 810 820 830 840
IFLLQAKDDK VLIVAGSKNT NIKAGDWIKN IAPIVGGGGG GRPDFAQAGG KDTSKIQEAK
850
TKALDYAKEN L