A8AZJ9
Gene name |
rpoA |
Protein name |
DNA-directed RNA polymerase subunit alpha |
Names |
RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha |
Species |
Streptococcus gordonii (strain Challis / ATCC 35105 / BCRC 15272 / CH1 / DL1 / V288) |
KEGG Pathway |
sgo:SGO_1959 |
EC number |
2.7.7.6: Nucleotidyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A8AZJ9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A8AZJ9-F1 | Predicted | AlphaFoldDB |
No variants for A8AZJ9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A8AZJ9 | |||||
No associated diseases with A8AZJ9
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.7.6 | Nucleotidyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| DNA-directed RNA polymerase complex | A protein complex that possesses DNA-directed RNA polymerase activity. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA-directed 5'-3' RNA polymerase activity | Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. |
| protein dimerization activity | The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA-templated transcription | The synthesis of an RNA transcript from a DNA template. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MIEFEKPNIT | KIDENKDYGK | FVVEPLERGY | GTTLGNSLRR | VLLASLPGAA | VTSINIEGVL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HEFDTIPGVR | EDVMQIILNI | KGIAVKSYVQ | DEKMIELDVE | GPAEITAGDI | LTDSDIEIVN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PDHYLFTIGE | GARFKAVMTV | NSGRGYVPAD | QNKRDDAPVG | TLAVDSIYTP | VTKVNYQVEP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ARVGSNDGFD | KLTLEIMTNG | TIIPEDALGL | SARILTEHLD | LFTDLTEVAK | ATDVMKEVDK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SSDDHVLERT | IEELDLSVRS | YNCLKRAGIN | TVYDLTEKTE | PEMMKVRNLG | RKSLEEVKIK |
| 310 | |||||
| LTDLGLGLKN | DK |