A8AWE1
Gene name |
thrB |
Protein name |
Homoserine kinase |
Names |
HK, HSK |
Species |
Streptococcus gordonii (strain Challis / ATCC 35105 / BCRC 15272 / CH1 / DL1 / V288) |
KEGG Pathway |
sgo:SGO_0802 |
EC number |
2.7.1.39: Phosphotransferases with an alcohol group as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A8AWE1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A8AWE1-F1 | Predicted | AlphaFoldDB |
No variants for A8AWE1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A8AWE1 | |||||
No associated diseases with A8AWE1
1 regional properties for A8AWE1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | CYRIA/CYRIB, Rac1 binding domain | 64 - 274 | IPR009828 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.1.39 | Phosphotransferases with an alcohol group as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| homoserine kinase activity | Catalysis of the reaction: L-homoserine + ATP = O-phospho-L-homoserine + ADP + 2 H(+). |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
| threonine biosynthetic process | The chemical reactions and pathways resulting in the formation of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKIIVPATSA | NIGPGFDSVG | VAVSKYLTIE | VLEERDEWLI | EHDLNPRIPK | DKRNLLIKVA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LQLAPNLQPY | RLKMTSDIPL | ARGLGSSSSV | IVAGIELANQ | LGKLDLTDDE | KLDWANKIEG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| HPDNVAPAIF | GNLVISSVFK | GAVSSVRADF | PECSFIAYVP | KYELKTRDSR | SVLPFKFSYK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EAVAASSIAN | VAIAALLQGD | LVKAGRAIES | DRFHERFRQK | LVREFPNIKK | LAKKHGAYAT |
| 250 | 260 | 270 | 280 | ||
| YLSGAGPTIM | ILAPKDRAKL | IQTRIEGCKY | NGEVFILDVD | RDGVRVEF |