A8ABX6

PR
Gene name
purL
Protein name
Phosphoribosylformylglycinamidine synthase subunit PurL
Names
FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II
Species
Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)
KEGG Pathway
iho:Igni_1252
EC number
6.3.5.3: Carbon--nitrogen ligases with glutamine as amido-N-donor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-73 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A8ABX6

Entry ID Method Resolution Chain Position Source
AF-A8ABX6-F1 Predicted AlphaFoldDB

No variants for A8ABX6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A8ABX6

No associated diseases with A8ABX6

5 regional properties for A8ABX6

Type Name Position InterPro Accession
domain PurM-like, C-terminal domain 182 - 335 IPR010918-1
domain PurM-like, C-terminal domain 550 - 674 IPR010918-2
domain PurM-like, N-terminal domain 59 - 171 IPR016188-1
domain PurM-like, N-terminal domain 418 - 538 IPR016188-2
domain Phosphoribosylformylglycinamidine synthase, linker domain 3 - 38 IPR041609

Functions

Description
EC Number 6.3.5.3 Carbon--nitrogen ligases with glutamine as amido-N-donor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
magnesium ion binding Binding to a magnesium (Mg) ion.
phosphoribosylformylglycinamidine synthase activity Catalysis of the reaction: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + ATP + H(2)O = 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate + ADP + 2 H(+) + phosphate.

1 GO annotations of biological process

Name Definition
'de novo' IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPLTEEELKL IEETLGRKPN QVELAMFEAQ WSEHCSYKSS RKHLRKLKMD SPWVVKGGDA
70 80 90 100 110 120
AVVDFGSVYV AFRIESHNHP SAVDPYNGAA TGVGGIIRDI LSSGAKPIAL LDDLIFGDLD
130 140 150 160 170 180
ENLVKWHVKG VVKGISDYGN RVGVPTVGGE TWFDPDFTRN PMVSVACVGV CPKDKLINGT
190 200 210 220 230 240
PRPGDLIVIA GNYTGKDGLL GSSFASKNLE EGVEEEYAAI QVPDPLMEKL LIDSILEMRD
250 260 270 280 290 300
ERLLVFVKDL GGGGLATALS EVAASFGLGV EARLDALHLR EPMEAWEIVV SESQERMMLV
310 320 330 340 350 360
IRPEDLERAK KVLEKYDVPY SVIGKFTDTG RVVLYYNGEK VADLPAKFLA EGPELDRPYE
370 380 390 400 410 420
RPKWHLELEL LPPLPEVDLG DAIRKVLSSP NVASKRWIYE QYDHEVQIRT VVKPGEGDAA
430 440 450 460 470 480
VLRLLEDPPK GIAVATDSNP RYTFLDPLWG AADVFLEAYR NVVASGARPL AAVDQVDAGS
490 500 510 520 530 540
PERPDRFWFF VRMIDGLAWV EREVDVPIVG GKVSFYNEDD VTGKQIKPTV MITMIGKVEN
550 560 570 580 590 600
VYNAKRARAE EGDLLVLVGE TFPELGGSEF LWSVHKLVRG KPPVPRPSTE ARVAERILKA
610 620 630 640 650 660
IKVSGVTGVH DVSVGGLAAA VAELAKGFGA TLELDKVKGP WKRPEEALFS ESGARYLLAV
670 680 690 700 710
KPEAAEEVLK VTGGTVVGKV GGGPLRVLLN GKEVASVDDF EDLLENGMTS RLV